2-[[2-(4-Methoxyphenyl)-2-oxoethyl]amino]-3-phenylpropanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[2-(4-Methoxyphenyl)-2-oxoethyl]amino]-3-phenylpropanoic acid
• 化学式: C₁₈H₁₉NO₄
• 分子量: 313.3
• InChiKey: GBGCVBGUZPUOBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• AMINO-KETONE SOLID SUPPORT TEMPLATES
  申请人：Advanced syntech, LLC

  公开号：EP1153050A1

  公开（公告）日：2001-11-14
• EP1153050A4
  申请人：——

  公开号：EP1153050A4

  公开（公告）日：2002-11-27
• US6117940A
  申请人：——

  公开号：US6117940A

  公开（公告）日：2000-09-12
• [EN] AMINO-KETONE SOLID SUPPORT TEMPLATES<br/>[FR] MATRICES A L'AMINO-CETONE POUR SUPPORTS SOLIDES
  申请人：ADVANCED SYNTECH LLC

  公开号：WO2000023487A1

  公开（公告）日：2000-04-27

  A solid support template for solid phase synthesis of amino group containing compounds is provided that comprises amino-ketone core compounds of the general formula: A-L-NH(CR1R2)nCOR3 linked to appropriate insoluble substrates to create solid support templates having the general formula: Polymer-X-L-NH(CR1R2)nCOR3 where L is a multifunctional monomer carrying a first functional group that forms a covalent bond with X and a second functional group comprising an amine and L, R1, R2 and R3 are selected from the group consisting of alkyl, alkyl-aryl, alkenyl, alkenyl-aryl groups having up to 6 carbon atoms and substituted forms thereof. The amino-ketones templates are useful for the solid phase synthesis of compounds such as the imidazoles, benzodiazepines, pyrazines, and steroid mimics.