4'--4,5',8-trimethylpsoralen

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4'--4,5',8-trimethylpsoralen
• 英文别名: 4'-(6-amino-2-aza)hexyl-4,5',8-trimethylpsoralen；3-[(4-Aminobutylamino)methyl]-2,5,9-trimethylfuro[3,2-g]chromen-7-one
• 化学式: C₁₉H₂₄N₂O₃
• 分子量: 328.411
• InChiKey: UYFTYGVWIVQFGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  77.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4'--4,5',8-trimethylpsoralen 在 三乙胺 作用下， 以 硝基甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 60.0h， 生成 5,10,15-tris(4-pyridyl)-20-<4-<4-(4,5',8-trimethylpsoralenylmethylamino)butylamino>-2,3,5,6-tetrafluorophenyl>porphyrin trismethiodide
  参考文献：
  名称：

  Wang, Xiao; Fedorova; Trumble, Russian Journal of Bioorganic Chemistry, 1999, vol. 25, # 3, p. 194 - 199

  摘要：

  DOI：

文献信息

• BATCH DEVICES FOR THE REDUCTION OF COMPOUNDS FROM BIOLOGICAL COMPOSITIONS CONTAINING CELLS AND METHODS OF USE
  申请人：——

  公开号：US20010018179A1

  公开（公告）日：2001-08-30

  Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.

  提供了一种方法和装置，用于在基于细胞的生物组成物中减少低分子量化合物的浓度，同时基本维持所需的生物活性。该装置包括高度多孔吸附剂颗粒，并且这些吸附剂颗粒被惰性基质固定。
• Absorbents and devices for the reduction of small organic compounds from blood products
  申请人：Cerus Corporation

  公开号：EP1508345A1

  公开（公告）日：2005-02-23

  The present invention relates to a system for use in treating a blood product containing a pathogen inactivating agent comprising a biocompatible housing and an adsorbent medium having (1) adsorbent resin particles capable of adsorbing the pathogen inactivating agent, and (2) an inert matrix in which the adsorbent resin particles are immobilized; wherein the immobilized adsorbent particles have a diameter from about 100 µm to about 1200 µm when the system is configured as a batch apparatus, and the immobilized adsorbent particles have a diameter from about 1 µm to about 200 µm when the system is configured as a flow-through apparatus; and wherein said blood product substantially maintains a desired biological activity after treatment with said system.

  本发明涉及一种用于处理含有病原体灭活剂的血液制品的系统，该系统包括生物相容性外壳和吸附介质，吸附介质具有(1)能够吸附病原体灭活剂的吸附树脂颗粒，和(2)固定吸附树脂颗粒的惰性基质；其中，当系统配置为间歇式装置时，固定吸附剂颗粒的直径约为 100 µm 至约 1200 µm，而当系统配置为流动式装置时，固定吸附剂颗粒的直径约为 1 µm 至约 200 µm；并且，在使用所述系统处理后，所述血液制品基本上保持了所需的生物活性。
• Photodecontamination of pathogens in blood
  申请人：Cerus Corporation

  公开号：EP1776952A2

  公开（公告）日：2007-04-25

  Psoralen compounds are synthesized which have substitutions on the 4, 4', 5' and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates methods for preparing substantially non-mutagenic blood products substantially free of nucleic acid, as well as said blood products as such, using the new psoralens which do not compromise the function of blood products for transfusion.

  所合成的补骨脂素化合物在补骨脂素的 4、4'、5'和 8 位上具有取代位，可增强与病原体核酸的结合。本发明描述了更高的补骨脂素结合水平和更低的诱变性，从而更安全、更有效、更可靠地灭活血液制品中的病原体。本发明考虑使用新型补骨脂素制备基本上不含核酸的非致突变性血液制品以及上述血液制品的方法，这些方法不会损害输血用血液制品的功能。
• Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
  申请人：——

  公开号：US20020045228A1

  公开（公告）日：2002-04-18

  Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.

  本发明提供了降低含有细胞的生物组合物中低分子量化合物浓度的方法和装置，同时基本保持了生物组合物所需的生物活性。该装置包括高多孔性吸附剂颗粒，吸附剂颗粒被惰性基质固定。
• ADSORBING PATHOGEN-INACTIVATING COMPOUNDS WITH POROUS PARTICLES IMMOBILIZED IN A MATRIX
  申请人：——

  公开号：US20040185553A9

  公开（公告）日：2004-09-23

  Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.

  本发明提供了降低含有细胞的生物组合物中低分子量化合物浓度的方法和装置，同时基本保持了生物组合物所需的生物活性。该装置包括高多孔性吸附剂颗粒，吸附剂颗粒被惰性基质固定。