Ile-Val-Leu

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ile-Val-Leu
• 英文别名: (2S)-2-[[(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoic acid
• 化学式: C₁₇H₃₃N₃O₄
• 分子量: 343.5
• InChiKey: UYODHPPSCXBNCS-XUXIUFHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Dry compositions comprising hydrophobic stabilisers
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1424066A1

  公开（公告）日：2004-06-02

  The object of the present invention is to provide a dry composition having the following advantageous properties. That is, even when left in a highly humid environment, the dry composition of the present invention scarcely loses its pharmacological activity, does not deliquesce and retains its dry state over a long period of time. A dry composition of the present invention comprises at least one of active ingredients selected from the group consisting of pharmacologically active proteins and pharmacologically active polypeptides and as a stabilizer at least one of hydrophobic stabilizers selected from the group consisting of hydrophobic amino acids, hydrophobic dipeptides and hydrophobic tripeptides.

  本发明的目的是提供一种具有以下优点的干燥组合物。也就是说，即使将本发明的干燥组合物置于高度潮湿的环境中，它也几乎不会失去药理活性，不会潮解，并能长期保持干燥状态。 本发明的干性组合物包括至少一种选自药理活性蛋白质和药理活性多肽组的活性成分，以及至少一种选自疏水氨基酸、疏水二肽和疏水三肽组的疏水稳定剂。
• Dry compositions
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US20030138402A1

  公开（公告）日：2003-07-24

  The object of the present invention is to provide a dry composition having the following advantageous properties. That is, even when left in a highly humid environment, the dry composition of the present invention scarcely loses its pharmacological activity, does not deliquesce and retains its dry state over a long period of time. A dry composition of the present invention comprises at least one of active ingredients selected from the group consisting of pharmacologically active proteins and pharmacologically active polypeptides and as a stabilizer at least one of hydrophobic stabilizers selected from the group consisting of hydrophobic amino acids, hydrophobic dipeptides and hydrophobic tripeptides.

  本发明的目的是提供一种具有以下优点的干燥组合物。也就是说，即使将本发明的干燥组合物置于高度潮湿的环境中，它也几乎不会失去药理活性，不会潮解，并能长期保持干燥状态。 本发明的干性组合物包括至少一种选自药理活性蛋白质和药理活性多肽组的活性成分，以及至少一种选自疏水氨基酸、疏水二肽和疏水三肽组的疏水稳定剂。
• DRY COMPOSITIONS
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0869816A1

  公开（公告）日：1998-10-14
• DRY COMPOSITIONS COMPRISING HYDROPHOBIC STABILIZERS
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0869816B1

  公开（公告）日：2004-12-15
• [EN] DRY COMPOSITIONS<br/>[FR] COMPOSITIONS SECHES
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：WO1997023239A1

  公开（公告）日：1997-07-03

  (EN) The object of the present invention is to provide a dry composition having the following advantageous properties. That is, even when left in a highly humid environment, the dry composition of the present invention scarcely loses its pharmacological activity, does not deliquesce and retains its dry state over a long period of time. A dry composition of the present invention comprises at least one of active ingredients selected from the group consisting of pharmacologically active proteins and pharmacologically active polypeptides and as a stabilizer at least one of hydrophobic stabilizers selected from the group consisting of hydrophobic amino acids, hydrophobic dipeptides and hydrophobic tripeptides.(FR) L'invention porte sur une composition sèche ayant les propriétés suivantes. Même en présence d'une forte humidité, elle perd très peu de son activité pharmacologique, elle ne se liquéfie pas et elle conserve son état sec sur de longues périodes. Ladite composition comporte au moins l'un des principes actifs choisis parmi des protéines et des polypeptides à activité pharmacologique et, comme stabilisateur, au moins un stabilisateur hydrophobe choisi parmi des acides aminés, des dipeptides et des tripeptides, hydrophobes.