6-(3-Cyclopentyloxy-4-methoxyphenyl)-8,9-dimethyl-3-oxa-1-azaspiro[4.5]dec-8-en-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 6-(3-Cyclopentyloxy-4-methoxyphenyl)-8,9-dimethyl-3-oxa-1-azaspiro[4.5]dec-8-en-2-one
• 化学式: C₂₂H₂₉NO₄
• 分子量: 371.5
• InChiKey: DUPLFHKYPXLEPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Methods of inducing ovulation using a non-polypeptide camp level modulator
  申请人：Laboratoires Serono SA

  公开号：EP1908463A2

  公开（公告）日：2008-04-09

  The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.

  本发明涉及诱导雌性宿主排卵的方法，包括向雌性宿主施用非多肽环磷酸腺苷（cAMP）水平调节剂。在另一方面，本发明提供了在宿主排卵周期的黄体期之前特异性给药磷酸二酯酶抑制剂的方法。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同工酶抑制剂。
• Methods of inducing ovulation
  申请人：——

  公开号：US20020103106A1

  公开（公告）日：2002-08-01

  The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.

  本发明涉及诱导雌性宿主排卵的方法，包括向雌性宿主施用非多肽环磷酸腺苷（cAMP）水平调节剂。在另一方面，本发明提供了在宿主排卵周期的黄体期之前特异性给药磷酸二酯酶抑制剂的方法。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同工酶抑制剂。
• METHODS OF INDUCING OVULATION-USING A NON-POLYPEPTIDE CAMP LEVEL MODULATOR
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1463493A1

  公开（公告）日：2004-10-06
• 非ポリペプチドｃＡＭＰレベル調節剤を使用する排卵誘発方法
  申请人：アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ

  公开号：JP4532115B2

  公开（公告）日：2005-06-09
• METHODS OF INDUCING OVULATION
  申请人：Palmer Stephen

  公开号：US20060293222A1

  公开（公告）日：2006-12-28

  The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.