2-[[(3S,4R)-1-pentyl-4-thiophen-2-ylpiperidin-3-yl]methoxy]benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[[(3S,4R)-1-pentyl-4-thiophen-2-ylpiperidin-3-yl]methoxy]benzonitrile
• 化学式: C₂₂H₂₈N₂OS
• 分子量: 368.5
• InChiKey: AGQJBTOMHBHWMQ-VQTJNVASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] USE OF 3,4-SUBSTITUTED PIPERIDINES<br/>[FR] UTILISATION DE PIPERIDINES 3,4-SUBSTITUEES
  申请人：NOVO NORDISK AS

  公开号：WO2001032178A1

  公开（公告）日：2001-05-10

  The present invention relates to the use of compounds of the general formula (I) wherein R1 represents hydrogen, a straight or branched C¿1-8?-alkyl or C3-7-cycloalkyl group; and R?2 and R3¿ independently represent hydrogen, alkyl, alkynyl, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio, cyano, or aralkyloxy; and R?4 and R5¿ independently represent hydrogen, alkyl, C¿3-7?-cycloalkyl, alkynyl, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio, cyano, acylamino, methylsulfonyl, methylenedioxy, aryloxy or aralkyloxy, or R?4 and R5¿ together represent a methylenedioxy group; and Ar independently represents a phenyl, tetrahydronaphthyl or thienyl group; or a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical preparation for the : treatment, prevention, alleviation or amelioration of conditions in which there is alteration of blood pressure, hypotension, excessive vasodilation or migraine; treatment, prevention, alleviation or amelioration of memory and attention deficits resulting from but not limited to Alzheimer's disease, Parkinson's disease, trauma and stroke; treatment, prevention, alleviation or amelioration of painful conditions such as acute pain, chronic pain, arthritic pain or migraine; treatment, prevention, alleviation or amelioration of conditions in which there is excessive dopamine such as Schizophrenia, Parkinson's disease and depression; treatment, prevention, alleviation or amelioration of conditions in which there is symptoms of addictive drug withdrawal, including alcoholism; treatment, prevention, alleviation or amelioration of metabolic disorders such as hyperglycaemia, dyslipidemia, Type 1 diabetes, Type 2 diabetes, hypertriglyceridemia, syndrome X, insulin resistance, IGT or obesity. The present invention also embraces pharmaceutical compositions comprising these compounds and methods of using the compounds and their pharmaceutical compositions.