N-sec-butyl-4-chloro-3-(2-chloro-6-fluorophenyl)-1,6-naphthyridin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-sec-butyl-4-chloro-3-(2-chloro-6-fluorophenyl)-1,6-naphthyridin-2-amine
• 英文别名: N-butan-2-yl-4-chloro-3-(2-chloro-6-fluorophenyl)-1,6-naphthyridin-2-amine
• 化学式: C₁₈H₁₆Cl₂FN₃
• 分子量: 364.25
• InChiKey: VOQOVFBJYGNTGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-dichloro-3-(2-chloro-6-fluorophenyl)-1,6-naphthyridine 、 仲丁胺 在 silica gel 、 ethyl acetate n-hexane 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 以to give N-sec-butyl-4-chloro-3-(2-chloro-6-fluorophenyl)-1,6-naphthyridin-2-amine as a light yellow gum (0.08 g)的产率得到N-sec-butyl-4-chloro-3-(2-chloro-6-fluorophenyl)-1,6-naphthyridin-2-amine
  参考文献：
  名称：

  Fungicides

  摘要：

  式(I)中的萘啶衍生物以及用于防治或控制植物病原真菌的方法，包括将式(I)化合物应用于植物、植物种子和植物位置。

  公开号：

  US07947679B2

文献信息

• [EN] NAPHTHYRIDINE DERIVATIVES AND THEIR USE AS FUNGICIDES<br/>[FR] FONGICIDES
  申请人：SYNGENTA LTD

  公开号：WO2004056824A3

  公开（公告）日：2004-10-14
• NAPHTHYRIDINE DERIVATIVES AND THEIR USE AS FUNGICIDES
  申请人：Syngenta Limited

  公开号：EP1585746A2

  公开（公告）日：2005-10-19
• US7947679B2
  申请人：——

  公开号：US7947679B2

  公开（公告）日：2011-05-24
• [EN] FUNGICIDES<br/>[FR] FONGICIDES
  申请人：SYNGENTA LTD

  公开号：WO2004056824A2

  公开（公告）日：2004-07-08

  Fungicidal compositions of the general formula (1): wherein one of W, X, Y and Z is N and the others are CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy or halo(C1-4)alkyl, provided that when X is CH, Z is N, R is NHNH2, R1 is phenyl and R2 is Cl, W and Y are not both CCH3; one of R and R2 is NR3R4 and the other is halo, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylthio, C2-8 alkenyl, C2-8 alkynyl or cyano; R1 is aryl, heteroaryl, morpholino, piperidino or pyrrolidino; R3 and R4 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)-alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or R3 and R4 together form a C3-7 alkylene or C3-7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially N-methyl) ring; and R5 and R6 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(Cl-8)-alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-6 alkoxy, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 ialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl, C1-4 alkoxy(C1-6)alkyl, C 1-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NHCOR'', -NHCONR''R'', -CONK''R'', SO2R'', -OSO2R'', -COR'', -CR''=NR' or -N=CR ''R'', in which R'' and R'' are independently hydrogen, C1-4 alkyl, halo-(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C 1-4)alkyl, phenyl or benzyl groups beings optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy.