(2R)-2-acetamido-3-[(2-acetamido-2-carboxyethyl)disulfanyl]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-acetamido-3-[(2-acetamido-2-carboxyethyl)disulfanyl]propanoic acid
• 化学式: C₁₀H₁₆N₂O₆S₂
• 分子量: 324.4
• InChiKey: YTPQSLLEROSACP-JAMMHHFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  183
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Cysteine derivatives
  申请人：AJINOMOTO CO., INC.

  公开号：US20020115723A1

  公开（公告）日：2002-08-22

  Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

  本发明的目的是提供一种能够抑制细胞毒蛋白表达和基因转录调节因子激活的氧化应激抑制剂，该抑制剂在使用时具有良好的感觉和安全性；提供一种预防、延缓、缓解或治疗由氧化应激引起或促进的皮肤老化或不良美容皮肤变化的方法；提供一种含有氧化应激抑制剂作为有效成分的用于外用的化妆品组合物或皮肤科制剂。为了实现这些目的，使用一种氧化应激抑制剂，其有效成分包括至少一种来自半胱氨酸或半胱氨酸衍生物及其盐的物质。
• Compounds, Compositions and Methods for Treating or Preventing Hypoxic or Ischemic Injury
  申请人：Ruan Fuqiang

  公开号：US20110195945A1

  公开（公告）日：2011-08-11

  Compositions and methods of treating or preventing disease or injury to a human patient or biological material undergoing ischemic or hypoxic conditions.

  治疗或预防人类患者或生物材料在缺血或低氧条件下遭受疾病或损伤的组合物和方法。
• [EN] THE PHARMACOLOGICAL USE OF CERTAIN CYSTINE DERIVATIVES
  申请人：AKTIEBOLAGET ASTRA

  公开号：WO1991018594A1

  公开（公告）日：1991-12-12

  (EN) A method for the treatment of diseases due to defects in the immune system using certain cystine derivatives and a pharmaceutical preparation comprising these derivatives.(FR) L'invention se rapporte à un procédé qui sert à traiter des affections dues à des défaillances du système immunitaire et qui utilise certains dérivés de cystine, ainsi qu'à une préparation pharmaceutique contenant de tels dérivés.

  一种使用特定半胱氨酸衍生物治疗免疫系统缺陷疾病的方法，以及包含这些衍生物的制药制剂。
• [EN] PROCESS OF MAKING N,N'-DIACETYL-L-CYSTINE<br/>[FR] PROCÉDÉ DE PRODUCTION DE N,N'-DIACÉTYL-L-CYSTINE
  申请人：UNILEVER IP HOLDINGS B V

  公开号：WO2021219375A1

  公开（公告）日：2021-11-04

  An effective process of making Ν,Ν'-diacetyl-L-Cystine ("NDAC"), which process is fast, green, does not require labor-intensive isolation or purification of the product, by yielding products in desired ratio, and has improved yield and purity. The process comprising the steps of Forming a reaction mixture, starting with a cystine derivative di-tert- butyl-L-cystine as the dihydrochloride form; Acetylating said di-tert-butyl-L-cystine to obtain Ν,Ν'-diacetyl-di-tert- butyl-L-cystine; followed by Removing said tert- butyl groups from said Ν,Ν'-diacetyl-di-tert-butyl- L-cystine to obtain Ν,Ν'-diacetyl-L-cystine product; and Isolating said Ν,Ν'-diacetyl-L-Cystine product from said reaction mixture; wherein said acetylating agent is acetic anhydride.

  一种制备Ν,Ν'-二乙酰-L-半胱氨酸（“NDAC”）的有效过程，该过程快速、环保，不需要耗费大量劳动力进行产品的分离或纯化，通过产生所需比例的产物，且产量和纯度得到改善。该过程包括以下步骤：形成反应混合物，以二叔丁基-L-半胱氨酸衍生物二叔丁基-L-半胱氨酸二盐酸盐形式为起始物；乙酰化该二叔丁基-L-半胱氨酸以获得Ν,Ν'-二乙酰-二叔丁基-L-半胱氨酸；随后从Ν,Ν'-二乙酰-二叔丁基-L-半胱氨酸中去除叔丁基基团以获得Ν,Ν'-二乙酰-L-半胱氨酸产物；并从所述反应混合物中分离所述Ν,Ν'-二乙酰-L-半胱氨酸产物；其中所述乙酰化试剂为乙酸酐。
• Dehydrated amino acid food additives, their preparation and use in foodstuffs
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0022361A1

  公开（公告）日：1981-01-14

  This invention relates to improved nutritionally useful, amino acid food additives, the method of making them and the fortification of foodstuffs which are deficient in the nutritionally related amino acids. This improved amino acid food additive comprises a uniform dehydrated cocrystalline matrix of (1) an amino acid material, preferably a salt of an essential amino acid material, and (2) an effective amount of a soluble edible cocrystallizer material, preferably sodium chloride, whereby the improved amino acid food additive provided is better-tasting, more stable and less hygroscopic than the free amino acid material alone. A preferred improved amino acid food additive is made by dissolving 118 grams of L-lysine hydrochloride, 62 grams of N-acetyl L-methionine (NALM), 42 grams of L-threonine and 240 grams sodium chloride into 800 grams of water at 150°F. The salts of L-lysine, NALM and L-threonine are provided by neutralizing the solution with sodium hydroxide to a pH of 6.8. Then the solution is freeze dried to provide a stable dehydrated uniform cocrystalline matrix of the salts of said amino acids and NaCl. Peanut butter fortified with this improved additive is more stable and better tasting than one made with free amino acids.

  本发明涉及改进的营养型氨基酸食品添加剂、其制造方法以及营养相关氨基酸缺乏食品的强化。这种改良的氨基酸食品添加剂由均匀的脱水球晶基质组成，基质包括（1）氨基酸材料，最好是必需氨基酸材料的盐；（2）有效量的可溶性可食用球晶材料，最好是氯化钠，由此提供的改良氨基酸食品添加剂比单独的游离氨基酸材料口感更好、更稳定、吸湿性更低。一种优选的改进型氨基酸食品添加剂是将 118 克 L-赖氨酸盐酸盐、62 克 N-乙酰基 L-蛋氨酸（NALM）、42 克 L-苏氨酸和 240 克氯化钠溶解到 800 克 150 华氏度的水中制成的。用氢氧化钠将溶液中和至 pH 值为 6.8，以提供 L-赖氨酸、NALM 和 L-苏氨酸的盐。然后对溶液进行冷冻干燥，以提供由上述氨基酸盐和氯化钠组成的稳定的脱水均匀的共晶基质。使用这种改良添加剂强化的花生酱比使用游离氨基酸制成的花生酱更稳定，口感更好。