N-(3-carbamimidoylphenyl)-2-[6-(1-ethanimidoylpiperidin-4-yl)oxy-2,2,4-trioxo-2lambda6,1,3-benzothiadiazin-1-yl]acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(3-carbamimidoylphenyl)-2-[6-(1-ethanimidoylpiperidin-4-yl)oxy-2,2,4-trioxo-2lambda6,1,3-benzothiadiazin-1-yl]acetamide
• 英文别名: N-(3-carbamimidoylphenyl)-2-[6-(1-ethanimidoylpiperidin-4-yl)oxy-2,2,4-trioxo-2λ6,1,3-benzothiadiazin-1-yl]acetamide
• 化学式: C₂₃H₂₇N₇O₅S
• 分子量: 513.6
• InChiKey: FEUHUMKNZYJASW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  190
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Pharmaceutical Composition Comprising A Plurality of Mini-Tablets Comprising A Factor XA Inhibitor
  申请人：Abu-Baker Omar Abdelfattah

  公开号：US20090285887A1

  公开（公告）日：2009-11-19

  A modified release pharmaceutical composition for oral administration comprising plural mini-tablets, comprising a therapeutically effective amount of a Factor Xa inhibitor within a matrix of polymer(s). The mini-tablets are suitably encapsulated within a gelatin capsule. A manufacturing process and method of use are also described.
• [EN] DOSAGE FORMULATIONS AND METHODS OF TREATMENT AND PREVENTION<br/>[FR] PREPARATIONS PHARMACEUTIQUES ET PROCEDES DE TRAITEMENT ET DE PREVENTION
  申请人：GLAXO GROUP LTD

  公开号：WO2006110726A2

  公开（公告）日：2006-10-19

  [EN] The present invention relates to combinations of 4-methyl-2-oxo-2H-1-benzopyran-7-yl-5-thio-ß-D-xylopyranoside and factor Xa inhibitors, methods for producing said combinations, and methods of using said combinations for the treatment and prevention of various thromboembolic disorders in mammals, particularly humans.
  [FR] La présente invention concerne des combinaisons de 4-méthyl-2-oxo-2H-1-benzopyran-7-yl-5-thio-ß-D-xylopyranoside et d'inhibiteurs du facteur Xa, des procédés pour produire ces combinaisons et des procédés pour utiliser ces combinaisons afin de traiter et de prévenir divers troubles thromboemboliques chez les mammifères, en particulier chez l'homme.