(2R)-2-[(2-aminobenzoyl)amino]-3-phenylpropanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-[(2-aminobenzoyl)amino]-3-phenylpropanoic acid
• 化学式: C₁₆H₁₆N₂O₃
• 分子量: 284.31
• InChiKey: CDGIMWSYQRLCDM-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] ANTHRANYL DERIVATIVES HAVING AN ANTICHOLECYSTOKININ ACTIVITY (ANTI-CCK-1), A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL USE THEREOF<br/>[FR] DERIVES D'ANTHRANYLE AYANT UNE ACTIVITE ANTICHOLECYSTOKININE (ANTI-CCK-1), LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE
  申请人：ROTTA RESEARCH LAB

  公开号：WO2004013087A1

  公开（公告）日：2004-02-12

  Anthranylic compounds having anti-CCK activity of general formula (I) in which, n is a whole number lying between 0 and 7; R1 is chosen independently from the groups (II), in which X1 is chosen independently from, S, O, NR2 and X2 is a group chosen from: H, C1-C4 alkyl, F, Cl, CF3, OCH3, OC2H5, CN; R2 is chosen from H or CH3; R3 is chosen from H, CH3, F, Cl, CF3, OCH3; R4 is chosen from the groups: H, -S-(CH2)m-R5, -SO2- (CH2)m-R5 (n different from 0), a branched alkyl group, a cyclo alkyl, a cyclo alkenyl, the group 1 or 2 adamantile, a phenyl group optionally substituted; R5 is chosen from the groups: H, linear or branched alkyl, cyclo alkyl, the group 1 or 2 adamantile, a suitably substituted phenyl group.

  具有抗CCK活性的Anthranylic化合物的一般式（I），其中，n是介于0和7之间的整数；R1独立地选择自群体（II），其中X1独立地选择自S、O、NR2和X2选择自：H、C1-C4烷基、F、Cl、CF3、OCH3、OC2H5、CN的群体；R2选择自H或CH3；R3选择自H、CH3、F、Cl、CF3、OCH3；R4选择自群体：H、-S-（CH2）m-R5、-SO2-（CH2）m-R5（n不等于0）、支链烷基、环烷基、环烯基、1或2-金刚烷基、可选取代的苯基；R5选择自群体：H、线性或支链烷基、环烷基、1或2-金刚烷基、适当取代的苯基。
• Anthranyl derivatives having an anticholecystokinin activity (anti-cck-1), a process for their preparation, and pharmaceutical use thereof
  申请人：Makovec Francesco

  公开号：US20060111304A1

  公开（公告）日：2006-05-25

  Anthranylic compounds having anti-CCK activity of general formula (I) in which, n is a whole number lying between 0 and 7; R 1 is chosen independently from the groups (II), in which X 1 is chosen independently from, S, O, NR 2 and X 2 is a group chosen from: H, C 1 -C 4 alkyl, F, Cl, CF 3 , OCH 3 , OC 2 H 5 , CN; R 2 is chosen from H or CH 3 ; R 3 is chosen from H, CH 3 , F, Cl, CF 3 , OCH 3 ; R 4 is chosen from the groups: H, —S—(CH 2 )m-R 5 , —SO 2 —(CH 2 )m-R 5 (n different from 0), a branched alkyl group, a cyclo alkyl, a cyclo alkenyl, the group 1 or 2 adamantile, a phenyl group optionally substituted; R 5 is chosen from the groups: H, linear or branched alkyl, cyclo alkyl, the group 1 or 2 adamantile, a suitably substituted phenyl group.

  通式(I)的具有抗 Cck 活性的蒽化合物 其中，n 是介于 0 和 7 之间的整数；R 1 独立选自基团 (II)，其中 X 1 独立选自 S、O、NR 2 和 X 2 是一个选自以下的基团 1 -C 4 烷基、F、Cl、CF 3 OCH 3 OC 2 H 5 CN; R 2 选自 H 或 CH 3 ; R 3 选自 H、CH 3 F、Cl、CF 3 OCH 3 ; R 4 选自以下基团：H、-S-(CH 2 )m-R 5 、-SO 2 -(CH 2 m-R 5 (n不同于0)、支链烷基、环烷基、环烯基、基团1或2金刚烷基、任选取代的苯基；R 5 选自以下基团：H、直链或支链烷基、环烷基、1 或 2 金刚烷基、经适当取代的苯基。
• ANTHRANYL DERIVATIVES HAVING AN ANTICHOLECYSTOKININ ACTIVITY (ANTI-CCK-1), A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL USE THEREOF
  申请人：Rottapharm S.p.A.

  公开号：EP1532105A1

  公开（公告）日：2005-05-25
• US7294648B2
  申请人：——

  公开号：US7294648B2

  公开（公告）日：2007-11-13