N-acetyl-S-nitroso-D-cysteinyl-L-proline

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-S-nitroso-D-cysteinyl-L-proline
• 英文别名: (2S)-1-[(2S)-2-acetamido-3-nitrososulfanylpropanoyl]pyrrolidine-2-carboxylic acid
• 化学式: C₁₀H₁₅N₃O₅S
• 分子量: 289.312
• InChiKey: MZMWJGGPYBNRBH-SFYZADRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  141
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces
  申请人：BRIGHAM & WOMEN'S HOSPITAL

  公开号：EP1393723A2

  公开（公告）日：2004-03-03

  The invention is directed to the use of therapeutically effective amount of a nitric oxide adduct for the manufacture of a pharmaceutical preparation for the treatment of artherosclerosis or hyperhomocysteinemia.

  本发明涉及使用治疗有效量的一氧化氮加合物制造治疗动脉粥样硬化或高同型半胱氨酸血症的药物制剂。
• High yield S-nitrosylation process
  申请人：——

  公开号：US20020062020A1

  公开（公告）日：2002-05-23

  A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently mixing the solution (e.g., by vigorously stirring the solution) to produce the S-nitrosylated species; and (c) isolating the S-nitrosylated species. The nitrite-bearing species can be, for example, an inorganic nitrite, such as an alkali metal nitrite, or an organic nitrite, such as an alkyl nitrite (e.g., ethyl nitrite, amyl nitrite, isobutyl nitrite or t-butyl nitrite). The thiol is preferably a thiol-containing polysaccharide, a thiol-containing lipoprotein, a thiol-containing amino acid or a thiol-containing protein, and more preferably a thiol-containing polysaccharide such as thiolated cyclodextrin. In many preferred embodiments, the S-nitrosylated species is insoluble in the acidified solution, precipitating upon formation. The S-nitrosylated species can be isolated, for example, by a process in which the precipitate is removed from the solution (e.g., by centrifugation) and the aqueous solvent remaining in the precipitate is sublimated (e.g., by freezing the precipitate and subjecting it to a vacuum). The isolated S-nitrosylated product is preferably protected from heat, light, moisture and oxygen.

  本发明提供了一种生产 S-亚硝基化物的方法。该方法包括：(a) 提供包含硫醇和亚硝酸盐的脱氧碱性水溶液；(b) 通过向溶液中添加酸来酸化溶液，同时搅拌溶液（例如，剧烈搅拌溶液）以产生 S-亚硝基化物；以及 (c) 分离 S-亚硝基化物。例如，含亚硝酸盐的物质可以是无机亚硝酸盐，如碱金属亚硝酸盐，或有机亚硝酸盐，如烷基亚硝酸盐（如亚硝酸乙酯、亚硝酸戊酯、亚硝酸异丁酯或亚硝酸叔丁酯）。硫醇优选为含硫醇的多糖、含硫醇的脂蛋白、含硫醇的氨基酸或含硫醇的蛋白质，更优选为含硫醇的多糖，如硫醇化的环糊精。在许多优选的实施方案中，S-亚硝基化物不溶于酸化溶液，在形成后沉淀。S 亚硝基化物可通过以下方法分离出来：例如，将沉淀从溶液中去除（如通过离心），然后将沉淀中残留的水溶剂升华（如通过冷冻沉淀并将其置于真空中）。分离出的 S-亚硝基化产物最好能避开热、光、湿气和氧气。
• Localized use of nitric oxide-adducts to prevent internal tissue damage
  申请人：——

  公开号：US20030072783A1

  公开（公告）日：2003-04-17

  A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide adduct can be present in a matrix coating on a surface of the medical device; can be coated per se on a surface of the medical device; can be directly or indirectly bound to reactive sites on a surface of the medical device; or at least a portion of the medical device can be formed of a material, such as a polymer, which includes the nitric oxide adduct. Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue.

  一种预防与患者使用医疗器械有关的不良反应的方法，方法是将至少一部分含有预防或治疗量的一氧化氮加合物的器械引入患者体内。一氧化氮加合物可以存在于医疗设备表面的基质涂层中；可以本身涂覆在医疗设备表面；可以直接或间接地与医疗设备表面的反应位点结合；或者医疗设备的至少一部分可以由包括一氧化氮加合物的材料（如聚合物）形成。本发明还公开了一种方法，通过在医疗过程中引入医疗设备，并在所述过程之前或期间在所述设备与任何内部组织的接触部位局部施用一氧化氮加合物，来预防与患者使用医疗设备相关的不良反应。
• Use of nitric oxide adducts
  申请人：——

  公开号：US20040037836A1

  公开（公告）日：2004-02-26

  A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide adduct can be present in a matrix coating on a surface of the medical device; can be coated per se on a surface of the medical device; can be directly or indirectly bound to reactive sites on a surface of the medical device; or at least a portion of the medical device can be formed of a material, such as a polymer, which includes the nitric oxide adduct. Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue.

  一种预防与患者使用医疗器械有关的不良反应的方法，方法是将至少一部分含有预防或治疗量的一氧化氮加合物的器械引入患者体内。一氧化氮加合物可以存在于医疗设备表面的基质涂层中；可以本身涂覆在医疗设备表面；可以直接或间接地与医疗设备表面的反应位点结合；或者医疗设备的至少一部分可以由包括一氧化氮加合物的材料（如聚合物）形成。本发明还公开了一种方法，通过在医疗过程中引入医疗设备，并在所述过程之前或期间在所述设备与任何内部组织的接触部位局部施用一氧化氮加合物，来预防与患者使用医疗设备相关的不良反应。
• EP0724436A4
  申请人：——

  公开号：EP0724436A4

  公开（公告）日：1999-09-01