5-(2,4,5-trimethoxy-benzyl)-pyrimidine-2,4-diamine | 6981-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(2,4,5-trimethoxy-benzyl)-pyrimidine-2,4-diamine
• 英文别名: 2,4-diamino-5-(3,4,6-trimethoxybenzyl)pyrimidine；2,4-NH2Pyrimidine,5(2,4,5-meo)benzyl；5-[(2,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
• CAS: 6981-01-7
• 化学式: C₁₄H₁₈N₄O₃
• 分子量: 290.322
• InChiKey: IEAAAQXTROJCRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Bio-agent delivery systems based on coated degradable biocompatible hydrogels
  申请人：UNIVERSITEIT GENT

  公开号：EP1733718A1

  公开（公告）日：2006-12-20

  A microcapsule of a degradable biocompatible hydrogel being coated by two or more alternating layers of at least one positively charged biocompatible polypeptide selected from the group consisting of poly-L-arginine and poly-L-ornithine and at least one biocompatible polyanion selected from the group consisting of dextran sulfate, chondroitin sulfate, poly-L-glutamic acid and poly-L-aspartic acid.

  一种可降解的生物相容性水凝胶微囊，被至少一种来自聚-L-精氨酸和聚-L-鸟氨酸的正电生物相容性多肽和来自右旋糖酸硫酸酯、软骨素硫酸酯、聚-L-谷氨酸和聚-L-天冬氨酸的生物相容性聚阴离子交替层包覆。
• PROCESS FOR RELEASE OF BIOLOGICALLY ACTIVE SPECIES
  申请人：AUGUSTIJNS Patrick

  公开号：US20090318519A2

  公开（公告）日：2009-12-24

  A process for the release of a biologically active species comprising the steps of: providing a mesoporous oxide-based material having structural order and at least one level of porosity; fixing or immobilizing said biologically active species in said ordered mesoporous oxide; and providing said ordered mesoporous oxide with said fixed or immobilized biologically active species in vivo thereby realizing intraluminally induced substantially pH-independent supersaturation of said biologically active species resulting in enhanced transepithelial transport; wherein said biologically active species is a poorly soluble therapeutic drug classified as belonging to Class II or Class IV of the Biopharmaceutical Classification System and said ordered mesoporous oxide has a pore size in the range of 4 to 14 nm.

  一种释放生物活性物种的方法，包括以下步骤：提供具有结构有序性和至少一级多孔性的介孔氧化物基材料；将所述生物活性物种固定或固定化在所述有序介孔氧化物中；并在体内提供具有所述固定或固定化生物活性物种的有序介孔氧化物，从而实现基腔内诱导的基本上pH无关的生物活性物种过饱和度，导致增强的经上皮转运；其中，所述生物活性物种是属于生物制药分类系统的II类或IV类的难溶性治疗药物，所述有序介孔氧化物的孔径在4到14纳米范围内。
• Aqueous coacervate compositions suitable for making powders and water-soluble formulations of biologically-active agents
  申请人：Universiteit Gent

  公开号：EP2407156A2

  公开（公告）日：2012-01-18

  This invention relates to an aqueous gel-free two-phase coacervate composition comprising a coacervate phase and an equilibrium water phase, comprising a mixture of: (a) a poorly water-soluble bio-active agent, (b) a tensio-active system with a HLB from 8 to 18 and consisting of non-ionic tensio-active agents, (c) one or more water-soluble carriers for said poorly water-soluble bio-active agent, said carriers being selected from the group consisting of polyols, and (d) water. Such coacervate compositions may be dried into solid dosage forms from which rapid release of the bio-active agent can be obtained.

  本发明涉及一种水性无凝胶两相助凝剂组合物，该组合物由助凝剂相和平衡水相组成，包含以下物质的混合物： (a) 低水溶性生物活性剂、 (b) HLB 介于 8 至 18 之间的抗张活性体系，由非离子抗张活性剂组成、 (c) 一种或多种水溶性载体，用于所述水溶性差的生物活性剂，所述载体选 自多元醇组成的组，以及 (d) 水。 这种凝聚态组合物可以干燥成固体剂型，从中可以快速释放生物活性剂。
• Method of producing a concentrate comprising a sulfonamide in solution, a 2,4-diaminopyrimidine in stable suspension within said solution
  申请人：——

  公开号：US20020183287A1

  公开（公告）日：2002-12-05

  A palatable antimicrobial drug concentrate comprising: (a) a sulfonamide and/or sulfonamide salt in aqueous solution; (b) a 2,4-diaminopyrimidine in stable suspension within said solution; and (c) a suspending agent. The invention has a long room temperature shelf life and is sufficiently stable to be administered via the drinking water of animals.

  一种适口性抗菌药物浓缩液，包括：(a)水溶液中的磺胺和/或磺胺盐；(b)在所述溶液中稳定悬浮的 2,4-二氨基嘧啶；以及(c)悬浮剂。本发明具有较长的室温保质期，并且足够稳定，可通过动物饮用水给药。
• Pharmaceutical compositions having differential drug release rate
  申请人：PITMAN-MOORE LIMITED

  公开号：EP0416722B1

  公开（公告）日：1994-09-28