2-[4-(3-fluorobenzyloxy)benzylamino]-3-hydroxy-propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[4-(3-fluorobenzyloxy)benzylamino]-3-hydroxy-propanamide
• 英文别名: 2-[[4-[(3-Fluorophenyl)methoxy]phenyl]methylamino]-3-hydroxypropanamide
• 化学式: C₁₇H₁₉FN₂O₃
• 分子量: 318.348
• InChiKey: UTIKAYGNKRMHTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  84.6
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1557166A1

  公开（公告）日：2005-07-27

  Methods of using certain α-aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects.

  使用某些α-氨基酰胺衍生物的方法来治疗下尿路障碍。该发明的治疗剂能够在没有副作用的情况下显著减少甚至停止下尿路障碍。
• ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS
  申请人：Izzo Emanuela

  公开号：US20110014304A1

  公开（公告）日：2011-01-20

  The disclosure relates to pharmacotherapy of a psychiatric disorder which is schizophrenia and/or anxiety, wherein schizophrenia includes schizophrenia related disorders such as brief psychotic disorders, delusional disorders, schizoaffective disorders, and schizophreniform disorders, and anxiety includes panic disorders, obsessive-compulsive disorders (OCD), post-traumatic stress disorders (PTSD), social phobia or social anxiety disorders, specific phobia, and generalized anxiety disorders (GAD). The compounds of the disclosure are useful for the treatment of the above psychiatric disorders alone or in combination with other therapeutical agents effective in the treatment of schizophrenia and/or anxiety disorders.

  本公开涉及药物治疗精神障碍，其中包括精神分裂症和/或焦虑症，其中精神分裂症包括与之相关的疾病，如短暂性精神病性障碍、妄想性障碍、情感性精神病性障碍和分裂症样障碍，而焦虑症包括惊恐障碍、强迫症、创伤后应激障碍、社交恐惧症或社交焦虑症、特定恐惧症和广泛性焦虑症。本公开的化合物可用于治疗上述精神障碍，单独使用或与其他治疗精神分裂症和/或焦虑症有效的治疗剂联合使用。
• Alpha-Aminoamide Derivatives Useful in the Treatment of Lower Urinary Tract Disorders
  申请人：Barbanti Elena

  公开号：US20080132567A1

  公开（公告）日：2008-06-05

  Methods of using certain α-aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects.

  使用某些α-氨基酰胺衍生物来治疗下尿路障碍的方法。本发明的治疗剂能够在几乎没有副作用的情况下显著减轻甚至停止下尿路障碍。
• Alpha-aminoamide derivatives useful as antimigraine agents
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1438956A1

  公开（公告）日：2004-07-21

  α-Aminoamide derivatives useful as antimigraine agents, particularly for the treatment of head pain conditions such as migraine, cluster headache or other severe headache, are disclosed. The antimigraine agents of the invention are able to reduce or even stop the pain deriving from such conditions without, virtually, any side effects.

  本发明公开了α-氨基酰胺衍生物，其可用作抗偏头痛剂，特别是用于治疗头痛症状，如偏头痛、集群头痛或其他严重头痛。本发明的抗偏头痛药物能够减轻或甚至停止由这些症状引起的疼痛，几乎没有任何副作用。
• Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
  申请人：Newron Pharmaceuticals S.p.A.

  公开号：EP1588704A1

  公开（公告）日：2005-10-26

  Methods of using certain α-aminoamide derivatives in the treatment of RLS and addictive disorders. The compounds of this invention are able to reduce or even stop the syntoms of RLS and addictive disorders substantially without side effects.

  使用某些 α-氨基酰胺衍生物治疗 RLS 和成瘾性疾病的方法。本发明的化合物能够大大减少甚至停止 RLS 和成瘾性疾病的综合症状，而不会产生副作用。