2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-3-hydroxy-1-propyl-L-valinate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-3-hydroxy-1-propyl-L-valinate
• 英文别名: [2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]-3-hydroxypropyl] (2R)-2-amino-3-methylbutanoate
• 化学式: C₁₄H₂₂N₆O₅
• 分子量: 354.366
• InChiKey: WPVFJKSGQUFQAP-YGPZHTELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  167
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  生成 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-3-hydroxy-1-propyl-L-valinate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Amorphous valganciclovir hydrochloride
  申请人：Sharma Kumar Mukesh

  公开号：US20070129385A1

  公开（公告）日：2007-06-07

  The present invention relates to an amorphous form of valganciclovir hydrochloride and the pharmaceutical compositions thereof. The amorphous form can be directly prepared by spray-drying or azeotropic distillation of reaction mass. The amorphous form is useful in treating viral infections, for example, herpes simplex and cytomegalovirus.
• PROCESS FOR THE PREPARATION OF AMORPHUS VALGANCYCLOVIR HYDROCHLORIDE
  申请人：Sethi Madhuresh Kumar

  公开号：US20130133289A1

  公开（公告）日：2013-05-30

  Amorphous valgancyclovir hydrochloride has a median particle size of below 100 μm. A process for the preparation of the compound includes dissolving valgancyclovir hydrochloride in at least one solvent, removing the solvents under moisture controlled conditions, and drying the wet mass.