(Z)-[4-[(2S)-2-acetamido-4-methylsulfanylbutanoyl]piperazin-1-yl]-methoxyimino-oxidoazanium

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-[4-[(2S)-2-acetamido-4-methylsulfanylbutanoyl]piperazin-1-yl]-methoxyimino-oxidoazanium
• 化学式: C12H23N5O4S
• 分子量: 333.41
• InChiKey: NHFBJENPFMPSMI-KFZGLNKMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Nitric oxide-releasing medical devices
  申请人：Office of Technology Transfer, National Institutes of Health

  公开号：US20020119115A1

  公开（公告）日：2002-08-29

  A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N 2 O 2 − functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.

  一种在生理条件下能释放一氧化氮的高分子组合物，包括生物高分子，例如肽，多肽，蛋白质，寡核苷酸或核酸，其中与一氧化氮释放的N2O2-功能团结合；包括该高分子组合物的药物组合物；以及治疗需要一氧化氮剂量治疗的生物疾病的方法。
• Pharmaceutical compositions comprising nitric oxide-releasing pyrrolidones
  申请人：The Government of the United States of America As represented by the Secretary of the Department Of Health and Human Services

  公开号：EP1666047A1

  公开（公告）日：2006-06-07

  A polymeric composition capable of releasing nitric oxide under physiological conditions comprises a biopolymer bound to a nitric oxide releasing N2O2- functional group of the formula: wherein J is a pyrrolidino group, bonded to N2O2- by its nitrogen atom, M+x is a pharmaceutically acceptable cation, where x is the valence of the cation, a is 1 and b and c are the smallest integers that result in a neutral compound.

  一种能在生理条件下释放一氧化氮的聚合物组合物包括与释放一氧化氮的 N2O2-官能团结合的生物聚合物，其官能团的化学式为 其中 J 是吡咯烷基团，通过其氮原子与 - 结合，M+x 是药学上可接受的阳离子，其中 x 是阳离子的价数，a 是 1，b 和 c 是产生中性化合物的最小整数。
• PHARMACEUTICAL COMPOSITIONS COMPRISING NITRIC OXIDE-RELEASING POLYSACCHARIDES
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0793500B1

  公开（公告）日：2006-05-03
• US5632981A
  申请人：——

  公开号：US5632981A

  公开（公告）日：1997-05-27
• US5700830A
  申请人：——

  公开号：US5700830A

  公开（公告）日：1997-12-23