2,2'-((2-((Carboxymethyl)(2-((carboxymethyl)amino)-ethyl)amino)ethyl)azanediyl)diacetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2'-((2-((Carboxymethyl)(2-((carboxymethyl)amino)-ethyl)amino)ethyl)azanediyl)diacetic acid
• 英文别名: 2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethylamino]acetic acid
• 化学式: C₁₂H₂₁N₃O₈
• 分子量: 335.31
• InChiKey: SLIOGOFAZDOJQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.6
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  168
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• [EN] CHEMICAL CONJUGATES OF EVANS BLUE DERIVATIVES AND THEIR USE AS RADIOTHERAPY AND IMAGING AGENTS<br/>[FR] CONJUGUÉS CHIMIQUES DE DÉRIVÉS DU BLEU D'EVANS ET LEUR UTILISATION COMME AGENTS DE RADIOTHÉRAPIE ET D'IMAGERIE
  申请人：US HEALTH

  公开号：WO2019070236A1

  公开（公告）日：2019-04-11

  The present invention is directed to a compound of Formula III or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: Formula III wherein the definitions of R1-R12 and L1-L4 are provided in the disclosure, wherein R13 is a chelating group comprising 177Lu, and wherein R14 is a peptide. The compounds of Formula I may be covalently bonded to a peptide via a linker to provide a compound of Formula III and thereby extend the half-life of the therapeutic compound. The invention is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use in the diagnosis or treatment of diseases.

  本发明涉及Formula III的化合物或其药学上可接受的酯、酰胺、溶剂合物或盐，或者该酯或酰胺的盐或该酯酰胺或盐的溶剂：Formula III，其中R1-R12和L1-L4的定义在披露中提供，其中R13是包含177Lu的螯合基团，其中R14是肽。Formula I的化合物可以通过连接剂与肽共价结合，以提供Formula III的化合物，从而延长治疗化合物的半衰期。本发明还涉及所述化合物的药物组合物，以及它们在诊断或治疗疾病中的用途。
• [EN] CHEMICAL CONJUGATES OF EVANS BLUE DERIVATIVES AND THEIR USE AS RADIOTHERAPY AND IMAGING AGENTS FOR TARGETING PROSTATE CANCER<br/>[FR] CONJUGUÉS CHIMIQUES DE DÉRIVÉS DE BLEU D'EVANS ET LEUR UTILISATION COMME AGENTS DE RADIOTHÉRAPIE ET D'IMAGERIE POUR LE CIBLAGE DU CANCER DE LA PROSTATE
  申请人：US HEALTH

  公开号：WO2019165200A1

  公开（公告）日：2019-08-29

  A compound of Formula (I) or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt wherein the definitions of R1-R13 and L1-L4 are provided in the disclosure, and wherein R14 is a group capable of binding to prostate-specific membrane antigen (PSMA).

  化合物式（I）或其药学上可接受的酯、酰胺、溶剂合物或盐，或其酯或酰胺的盐或其溶剂合物的盐，其中R1-R13和L1-L4的定义在披露中提供，且R14是能够结合到前列腺特异性膜抗原（PSMA）的基团。
• Dissociative fluorescence enhancement assay
  申请人：——

  公开号：US20030170907A1

  公开（公告）日：2003-09-11

  The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a &bgr;-dietone of formula I 1 wherein R 1 is an aryl, optionally mono- or multi-substituted, and R 2 is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms. The invention further relates to a bioaffinity assay using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection comprising the use of said enhancement solution.

  本发明涉及一种增强溶液，用于利用镧系离子或其螯合物作为标记物和解离荧光增强作为检测工具的测定技术，其中所述增强溶液包括式I的β-二酮，其中R1是芳基，可选地单取代或多取代，R2是直链或支链烷基链，具有2至9个碳原子，取代有四个或更多氟原子。本发明还涉及一种生物亲和测定，使用镧系离子或其螯合物作为标记物和解离荧光增强作为检测工具，包括使用所述增强溶液。
• METAL ADSORBENT CONTAINING CHELATING POLYMER
  申请人：Nippon Filcon Co., Ltd.

  公开号：EP2422878A1

  公开（公告）日：2012-02-29

  A metal adsorbent which can adsorb a wide variety of metals, can conform to various uses, and adsorbs metals in large amounts . Metal adsorbents in various forms, which have the property of highly efficiently adsorbing metals, are produced by (a) a method in which a polyamine polymer is chemically bonded and immobilized to a porous support, (b) a method in which a polyamine polymer is blended into a solution of a raw material for fibers and the mixture is formed into fibers by wet-spinning or dry spinning, and (c) a method in which a polyamine polymer is blended into a solution of a film-forming polymer and the mixture is formed into a film by a method of film formation from solution.

  一种金属吸附剂，它能吸附多种金属，符合各种用途，并能大量吸附金属。具有高效吸附金属特性的各种形式的金属吸附剂是通过以下方法生产的：(a) 将聚胺聚合物化学键合并固定在多孔支架上的方法、(b) 将聚胺聚合物与纤维原料溶液混合，然后通过湿法纺丝或干法纺丝将混合物制成纤维的方法；以及 (c) 将聚胺聚合物与成膜聚合物溶液混合，然后通过溶液成膜法将混合物制成薄膜的方法。
• METAL-ADSORBING GEL AND ADSORBENT SUPPORTING METAL-ADSORBING GEL
  申请人：Nippon Filcon Co., Ltd.

  公开号：EP2815811A1

  公开（公告）日：2014-12-24

  Problem The present invention provides, in a metal-adsorbing material used for the removal and recovery of a wide range of heavy metals in treated solutions such as industrial waste water, service water, and environmental water, a gel-like metal-adsorbing material having a large amount of metal adsorption and capable of meeting various demands; and also provide a metal adsorbent having a gel-like metal-adsorbing material supported on a porous carrier. Means for Resolution A metal-adsorbing polymer selected from polyethyleneimine and polyallylamine is crosslinked with a polyglycidyl ether, whereby a gel-like metal-adsorbing material having a large amount of metal adsorption and capable of meeting various demands is produced. Further, a hydrophilic porous carrier is impregnated with a metal-adsorbing polymer, followed by crosslinking with a polyglycidyl ether, whereby a metal adsorbent having a gel-like metal-adsorbing material supported on the porous carrier, which has a large amount of metal adsorption and can meet various demands, is produced.

  问题 本发明提供了一种用于去除和回收工业废水、服务用水和环境用水等处理溶液中多种重金属的金属吸附材料，该材料为凝胶状金属吸附材料，具有较大的金属吸附量，能够满足各种需求；同时还提供了一种金属吸附剂，该金属吸附剂具有支撑在多孔载体上的凝胶状金属吸附材料。 解决方法 将选自聚乙烯亚胺和聚烯丙基胺的金属吸附聚合物与聚缩水甘油醚交联，从而制备出具有大量金属吸附性并能满足各种需求的凝胶状金属吸附材料。进一步，在亲水性多孔载体上浸渍金属吸附聚合物，然后与聚缩水甘油醚交联，从而制得具有凝胶状金属吸附材料的金属吸附剂，该金属吸附剂支撑在多孔载体上，具有大量金属吸附性，可满足各种需求。