1-[2[4[5-Dimethylaminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1,2,3,6-tetrahydropyridin-1-yl]ethyl]-2-imidazolidinon

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-[2[4[5-Dimethylaminomethyl-1-(4-fluorophenyl)-1H-indol-3-yl]-1,2,3,6-tetrahydropyridin-1-yl]ethyl]-2-imidazolidinon
• 英文别名: 1-[2-[4-[5-[(dimethylamino)methyl]-1-(4-fluorophenyl)indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl]ethyl]imidazolidin-2-one
• 化学式: C₂₇H₃₂FN₅O
• 分子量: 461.582
• InChiKey: GWXCJGWWFPUZPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 5-aminoalkyl and 5-aminocarbonyl substituted indoles
  申请人：H. Lundbeck A/S

  公开号：US20020169169A1

  公开（公告）日：2002-11-14

  1 The present invention relates to 5-aminoalkyl and 5-aminocarbonyl substituted indole derivatives having formula (1), wherein R 1 is-(CH 2 ) n-1 -CONR 10 R 11 , -(CH 2 ) n -CONR 10 R 11 or (a), wherein R 10 and R 11 independently are selected from substituents defined herein; n is 1 to 3 and q is 2 to 5; G is N, C, or CH; Ar is phenyl optionally substituted with one or more substituents, or Ar is heterocyclic; R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from substituents defined herein; m is an integer from 2-6; W is O or S; U is N or CH; Z is —(CH 2 ) p -, p being 2 or 3, or Z is —CH═CH—or 1 ,2-phenylene, or Z is—COCH 2 - or —CSCH 2 -; V is O, S, CH 2 , or NR 9 ; X is N, C, or CH; Y is N, C, or CH; provided at least one of X and Y is N; or a pharmaceutically acceptable acid addition salt thereof. The novel 5-substituted indoles have high affinity for &agr; 1 -adrenoceptors and are considered useful for the treatment of diseases or disorders responsive to &agr; 1 -adrenoceptor antagonists. Further, as the compounds are selective &agr; 1 -adrenoceptor ligands they may be particularly useflul as PET or SPECT ligands.

  本发明涉及具有公式（1）的5-氨基烷基和5-氨基羰基取代的吲哚衍生物，其中R1是-(CH2)n-1-CONR10R11，-( )n-CONR10R11或（a），其中R10和R11独立地选择自此处定义的取代基；n为1至3，q为2至5；G为N、C或CH；Ar为苯基，可以选择一个或多个取代基进行取代，或Ar为杂环基；R2、R3、R4、R5和R6独立地选择自此处定义的取代基；m是2-6的整数；W为O或S；U为N或CH；Z为-（ ）p-，其中p为2或3，或Z为-CH=CH-或1,2-苯基，或Z为-CO -或-CS -；V为O、S、 或NR9；X为N、C或CH；Y为N、C或CH；其中至少一个为N；或其药学可接受的酸加合物。这些新型的5-取代吲哚具有高亲和力的α1-肾上腺素受体，被认为对于对α1-肾上腺素受体拮抗剂有反应的疾病或疾病的治疗有用。此外，由于这些化合物是选择性的α1-肾上腺素受体配体，它们可能特别有用作PET或SPECT配体。
• 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES
  申请人：H. LUNDBECK A/S

  公开号：EP1214312B1

  公开（公告）日：2004-04-14
• US6833376B2
  申请人：——

  公开号：US6833376B2

  公开（公告）日：2004-12-21