H-Tyr(Me)-gGlu-Cys-Gly-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Tyr(Me)-gGlu-Cys-Gly-OH
• 英文别名: (2S)-2-[[(2S)-2-amino-3-(4-methoxyphenyl)propanoyl]amino]-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
• 化学式: C₂₀H₂₈N₄O₈S
• 分子量: 484.5
• InChiKey: ISAVLYWCHCPBOW-KKUMJFAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  198
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• [EN] GLUTHIONE ANALOGUES AND THEIR USE AS ANTIOXIDANTS<br/>[FR] ANALOGUES DU GLUTATHION ET LEURS UTILISATIONS COMME ANTIOXYDANTS
  申请人：VULPES LTD

  公开号：WO2001096369A1

  公开（公告）日：2001-12-20

  Glutathione analogues are disclosed. These have Formula (I): X-Glu-Y-Gly-Z, wherein Glu is glutamyl or η-glutamyl, and Gly is glycine or glycyl, X is selected from the group consisting of H-; (O-R)tyrosyl; biotinyl-(O-R)tyrosyl; anthraniloyl-(O-R)tyrosyl; (O-R) tyrosyl-aminohexanoyl-; and 5-alkoxy tryptophyl-; Y is selected from the group consisting of cysteinyl, serinyl, methionyl or selenocysteinyl; and Z is selected from the group consisting of -H; (O-R)tyrosine; and aminohexanoyl-(O-R)tyrosine, and wherein each amino acids can be either a L- or a D- enantiomer; the peptide bonds may optionally be methylated, and the carboxyl groups are free acids, amides, or mono- or di-alkyl esters, and R is selected from alkyl, alkenyl, aryl and aryl containing one or several heteroatoms in the ring(s); with the provisio that X is not H when Y is L-cysteinyl and Gly is L-glycyl. Glutathione analogues for use as antioxidants, e.g. in cosmetics and pharmaceutical compositions, use of the gluthathione analogues for the manufacture of a medicament for the prophylactic and/or therapeutic treatment of a disease or disorder associated with oxidative degeneration of cells, such as Alzheimer's disease or Parkinson's disease, and a method of such treatment, are also described.