H-Lys-Leu-Val-Phe-NH2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Lys-Leu-Val-Phe-NH2
• 英文别名: (2S)-2,6-diamino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]hexanamide
• 化学式: C₂₆H₄₄N₆O₄
• 分子量: 504.7
• InChiKey: RAHWNEFTRFQYJM-CMOCDZPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  36
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  182
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Methods of synthesizing γ-AApeptides, γ-AApeptide building blocks, γ-AApeptide libraries, and γ-AApeptide inhibitors of Aβ40 aggregates
  申请人：UNIVERSITY OF SOUTH FLORIDA

  公开号：US10022420B2

  公开（公告）日：2018-07-17

  Embodiments of the present disclosure provide for γ-AApeptides, γ-AApeptide building blocks, methods of making γ-AApeptides and libraries of γ-AApeptides, methods of screening the γ-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for γ-AApeptides that are inhibitors of Aβ peptide aggregation, methods of inhibiting and disassembling Aβ peptide aggregation, methods of inhibiting the toxicity of Aβ aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.

  本公开的实施方案提供了γ-AA肽、γ-AA肽构建模块、制造γ-AA肽和γ-AA肽文库的方法、筛选γ-AA肽文库以获得所需拟肽活性的方法等。本公开还提供了抑制Aβ肽聚集的γ-AA肽、抑制和分解Aβ肽聚集的方法、抑制Aβ聚集体对N2a神经母细胞毒性的方法以及治疗阿尔茨海默病的方法和化合物。
• METHODS OF SYNTHESIZING GAMMA-AAPEPTIDES, GAMMA-AAPEPTIDE BUILDING BLOCKS, GAMMA-AAPEPTIDE LIBRARIES, AND GAMMA-AAPEPTIDE INHIBITORS OF ALPHA-BETA40 AGGREGATES
  申请人：Cai Jianfeng

  公开号：US20170232055A1

  公开（公告）日：2017-08-17

  Embodiments of the present disclosure provide for γ-AApeptides, γ-AApeptide building blocks, methods of making γ-AApeptides and libraries of γ-AApeptides, methods of screening the γ-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for γ-AApeptides that are inhibitors of Aβ peptide aggregation, methods of inhibiting and disassembling Aβ peptide aggregation, methods of inhibiting the toxicity of Aβ aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.