6-Amino-2-[2-[(biphenyl-4-ylmethyl)-amino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-Amino-2-[2-[(biphenyl-4-ylmethyl)-amino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid methyl ester
• 英文别名: methyl 6-amino-2-[[3-(1H-indol-3-yl)-2-[(4-phenylphenyl)methylamino]propanoyl]amino]hexanoate
• 化学式: C₃₁H₃₆N₄O₃
• 分子量: 512.652
• InChiKey: YKWCKKLENZHZAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  38
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  109
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
  申请人：——

  公开号：US20010047030A1

  公开（公告）日：2001-11-29

  Compounds according formula (I) A—G—Z—W and pharmaceutically acceptable salts, solvates or hydrates thereof; wherein, A is (C 6 -C 10 )aryl, (C 6 -C 10 )aryl-SO 2 , (C 6 -C 10 )aryl-CH 2 —, (C 6 -C 10 )arylcarbonyl, (C 1 -C 9 )heteroaryl, (C 1 -C 9 )heteroaryl-SO 2 —, (C 1 -C 9 )heteroaryl-CH 2 —; or (C 1 -C 9 )heteroarylcarbonyl; G is selected from the group consisting of: 1 where B is (C 6 -C 10 )aryl or (C 1 -C 9 )heteroaryl, and X is CH 2 , SO 2 , or carbonyl; 2 where X is CH 2 , SO 2 , or carbonyl; and R 1 and R 1′ are each independently selected from H, CN, (C 1 -C 8 )alkyl-, and phenyl(CH 2 )—, wherein said alkyl and phenyl groups are optionally substituted; and 3 where Z and W are as defined in the present Specificiation; and pharmaceutical compositions and methods useful to increase secretion of growth hormone(GH) from the anterior pituitary of mammals, including on a sustained release basis.

  根据化学式（I），提供化合物A-G-Z-W及其药学上可接受的盐类、溶剂或水合物；其中，A是（C6-C10）芳基，（C6-C10）芳基-SO2，（C6-C10）芳基-CH2-，（C6-C10）芳基羰基，（C1-C9）杂环芳基，（C1-C9）杂环芳基-SO2-，（C1-C9）杂环芳基- -；或（C1-C9）杂环芳基羰基；G选自以下组：1其中B是（C6-C10）芳基或（C1-C9）杂环芳基，X是 、SO2或羰基；2其中X是 、SO2或羰基，R1和R1'各自独立选择H、CN、（C1-C8）烷基或苯基（ ）-，其中所述烷基和苯基可以选用取代基；和3其中Z和W如本说明书中所定义；以及用于增加哺乳动物前垂体生长激素（GH）分泌的药物组合物和方法，包括持续释放的基础。
• Somatostatin antagonists and agonists that act at the sst subtype 2 receptor
  申请人：Hay A. Bruce

  公开号：US20050054581A1

  公开（公告）日：2005-03-10

  Compounds according formula (I) A-G-Z-W and pharmaceutically acceptable salts, solvates or hydrates thereof; wherein, A is (C 6 -C 10 )aryl, (C 6 -C 10 )aryl-SO 2 , (C 6 -C 10 )aryl-CH 2 —, (C 6 -C 10 )arylcarbonyl, (C 1 -C 9 )heteroaryl, (C 1 -C 9 )heteroaryl-SO 2 —, (C 1 -C 9 )heteroaryl-CH 2 —; or (C 1 -C 9 )heteroarylcarbonyl; G is selected from the group consisting of: where B is (C 6 -C 10 )aryl or (C 1 -C 9 )heteroaryl, and X is CH 2 , SO 2 , or carbonyl; where X is CH 2 , SO 2 , or carbonyl; and R 1 and R 1′ are each independently selected from H, CN, (C 1 -C 8 )alkyl-, and phenyl(CH 2 )—, wherein said alkyl and phenyl groups are optionally substituted; and where Z and W are as defined in the present Specificiation; and pharmaceutical compositions and methods useful to increase secretion of growth hormone(GH) from the anterior pituitary of mammals, including on a sustained release basis.

  根据公式（I）制备复合物A-G-Z-W及其药学上可接受的盐，溶剂或水合物；其中，A为（C6-C10）芳基，（C6-C10）芳基-SO2，（C6-C10）芳基-CH2—，（C6-C10）芳基羰基，（C1-C9）杂环芳基，（C1-C9）杂环芳基-SO2—，（C1-C9）杂环芳基- —；或（C1-C9）杂环芳基羰基；G选自以下组：其中B为（C6-C10）芳基或（C1-C9）杂环芳基，X为 ，SO2或羰基；其中X为 ，SO2或羰基；R1和R1'各自独立地选自H，CN，（C1-C8）烷基或苯基（ ）—，其中所述烷基和苯基基团可以选择性地被取代；Z和W的定义如本说明书所述；以及制备用于增加哺乳动物前垂体分泌生长激素（GH）的药物组合物和方法，包括持续释放的基础。
• US6495589B2
  申请人：——

  公开号：US6495589B2

  公开（公告）日：2002-12-17