(1R)-1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]-N,N-dimethylspiro[1,2-dihydroindene-3,4'-piperidine]-1-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1R)-1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]-N,N-dimethylspiro[1,2-dihydroindene-3,4'-piperidine]-1-carboxamide
• 化学式: C₃₁H₄₂N₄O₃
• 分子量: 518.7
• InChiKey: RDQVRDVGRUFPCB-AOYPEHQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  95.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Treatment For Alzheimer's Disease And Related Conditions
  申请人：Pineiro Jose Luis Castro

  公开号：US20080051403A1

  公开（公告）日：2008-02-28

  This invention provides the combination of a growth hormone secretagogue and a p38 kinase inhibitor for use in treatment or prevention of a disease associated with deposition of Aβ in the brain.
• [EN] COMBINATION OF GH SECRETAGOGUES AND PDE4 INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] THÉRAPIE COMBINÉE DESTINÉE À LA MALADIE D'ALZHEIMER
  申请人：MERCK SHARP & DOHME

  公开号：WO2004087157A2

  公开（公告）日：2004-10-14

  There is disclosed the treatment or prevention of diseases involving deposition of beta-amyloid in the brain, e.g. Alzheimer's disease, via the combined administration of a growth hormone secretagogue and a PDE4 inhibitor.
• [EN] TREATMENT FOR ALZHEIMER'S DISEASE AND RELATED CONDITIONS<br/>[FR] TRAITEMENT DE LA MALADIE D'ALZHEIMER ET DE PATHOLOGIES ASSOCIEES
  申请人：MERCK SHARP & DOHME

  公开号：WO2004110443A1

  公开（公告）日：2004-12-23

  There is disclosed the combination of a growth hormone secretagogue and at least one agent which modifies the production or processing of Aβ in the brain, said at least one agent being selected from: (a) compounds which inhibit the secretion of Aβ; (b) compounds which selectively inhibit the secretion of the 1-42 isoform of Aβ; (c) compounds which inhibit the aggregation of Aβ; and (d) antibodies which selectively bind to Aβ; for use in treatment or prevention of a disease associated with deposition of Aβ in the brain.