2-amino-N-{2-[3-benzyl-3-(N',N'-dimethylhydrazinocarbonyl)piperidin-1-yl]-1-((2-naphthyl)methyl)-2-oxo-ethyl}-2-methyl-propionamide | 249921-13-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-N-{2-[3-benzyl-3-(N',N'-dimethylhydrazinocarbonyl)piperidin-1-yl]-1-((2-naphthyl)methyl)-2-oxo-ethyl}-2-methyl-propionamide
• 英文别名: 2-amino-N-[(2R)-1-[3-benzyl-3-(dimethylaminocarbamoyl)piperidin-1-yl]-3-naphthalen-2-yl-1-oxopropan-2-yl]-2-methylpropanamide
• CAS: 249921-13-9
• 化学式: C₃₂H₄₁N₅O₃
• 分子量: 543.709
• InChiKey: AZLMMNIWIHHOHE-XIDOUCRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues
  申请人：Polvino J. William

  公开号：US20070191283A1

  公开（公告）日：2007-08-16

  The present invention relates to a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders or diseases) of the gastrointestinal system. The method comprises administering to a subject in need thereof a therapeutically effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof. The growth hormone secretagogue can be co-administered with a laxative, a H 2 receptor antagonist, a serotonin 5-HT 4 agonist, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.
• Method of treating cell proliferative disorders using growth hormone secretagogues
  申请人：Polvino William J.

  公开号：US20080207640A1

  公开（公告）日：2008-08-28

  The present invention relates to a method of treating cell proliferative disorders by administering to a subject an effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof.
• Methods of treating emesis using growth hormone secretagogues
  申请人：Mann William R.

  公开号：US20080300194A1

  公开（公告）日：2008-12-04

  The present invention relates to methods of treating or preventing emesis and improving a subject's ASAS score by administering to the subject an effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof.
• Method of Stimulating the Motility of the Gastrointestinal System Using Growth Hormone Secretagogues
  申请人：Polvino William J.

  公开号：US20100087381A1

  公开（公告）日：2010-04-08

  The present invention relates to a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders or diseases) of the gastrointestinal system. The method comprises administering to a subject in need thereof a therapeutically effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof. The growth hormone secretagogue can be co-administered with a laxative, a H 2 receptor antagonist, a serotonin 5-HT 4 agonist, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.
• METHODS OF TREATING EMESIS USING GROWTH HORMONE SECRETAGOGUES
  申请人：Mann William R.

  公开号：US20120232113A1

  公开（公告）日：2012-09-13

  The present invention relates to methods of treating or preventing emesis and improving a subject's ASAS score by administering to the subject an effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof.