Di-aryl substituted ethane pyridones, particularly ethane pyridones substituted with i) a phenyl, ii) a pyridyl, iii) a thiazole, iv) a pyrimidinyl, v) a pyridazinyl, vi) a furyl, vii) a thienyl, viii) an oxazolyl, ix) an isoxazolyl, or x) an isothiazolyl moiety are phosphodiesterase-4 inhibitors useful in the treatment or prevention of asthma; chronic bronchitis; chronic obstructive pulmonary disease; adult respiratory distress syndrome; infant respiratory distress syndrome; cough; chronic obstructive pulmonary disease in animals; adult respiratory distress syndrome; ulcerative colitis; Crohn's disease; hypersecretion of gastric acid; bacterial, fungal or viral induced sepsis or septic shock; endotoxic shock; laminitis or colic in horses; spinal cord trauma; head injury; neurogenic inflammation; pain; reperfusion injury of the brain; psoriatic arthritis; rheumatoid arthritis; ankylosing spondylitis; osteoarthritis; inflammation; or cytokine-mediated chronic tissue degeneration.
二芳基取代
乙烯吡啶酮,特别是
乙烯吡啶酮取代i)苯基,ii)
吡啶基,iii)
噻唑基,iv)
嘧啶基,v)
吡嗪基,vi)
呋喃基,vii)
噻吩基,viii)
噁唑基,ix)
异噁唑基,或x)异
硫氰酰基基团是
磷酸二酯酶-4
抑制剂,可用于治疗或预防哮喘;慢性支气管炎;慢性阻塞性肺疾病;成人呼吸窘迫综合征;婴儿呼吸窘迫综合征;咳嗽;动物慢性阻塞性肺疾病;成人呼吸窘迫综合征;溃疡性结肠炎;克罗恩病;胃酸过多;细菌、真菌或病毒引起的败血症或感染性休克;内毒素性休克;马蹄褥疮或腹绞痛;脊髓创伤;头部损伤;神经源性炎症;疼痛;脑再灌注损伤;
银屑病性关节炎;类风湿性关节炎;强直性脊柱炎;骨关节炎;炎症或细胞因子介导的慢性组织退化。