1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0 | 208538-69-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0
• 英文别名: [5-[2-[18-amino-3-(3-amino-1-hydroxy-3-oxopropyl)-11,20,21,25-tetrahydroxy-15-(1-hydroxyethyl)-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-6-yl]-1,2-dihydroxyethyl]-2-hydroxyphenyl] hydrogen sulfate
• CAS: 208538-69-6
• 化学式: C₃₅H₅₂N₈O₂₀S
• 分子量: 936.905
• InChiKey: QCYMOOBOFFUBHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9.3
• 重原子数：
  64
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  480
• 氢给体数：
  16
• 氢受体数：
  21

反应信息

• 作为产物：
  描述：

  WF11899A 在 immobilized cycloaliphatic peptide acyltransferase from Streptomyces sp. 6907 strain 作用下， 以 aq. phosphate buffer 为溶剂， 反应 4.0h， 生成 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0
  参考文献：
  名称：

  IMMOBILIZED CYCLOALIPHATIC PEPTIDE ACYLTRANSFERASE AND PREPARATION METHOD AND USES THEREOF

  摘要：

  Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic acyltransferase gene and transforming thereafter; the material of the carrier is selected from an inorganic carrier or a polypropylene resin carrier. Also disclosed in the present invention are the preparation method for the immobilized cycloaliphatic peptide acyltransferase and uses thereof.

  公开号：

  US20200149029A1

文献信息

• Immobilized cycloaliphatic peptide acyltransferase and preparation method and uses thereof
  申请人：SHANGHAI TECHWELL BIOPHARMACEUTICAL CO., LTD

  公开号：US11518990B2

  公开（公告）日：2022-12-06

  Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic acyltransferase gene and transforming thereafter; the material of the carrier is selected from an inorganic carrier or a polypropylene resin carrier. Also disclosed in the present invention are the preparation method for the immobilized cycloaliphatic peptide acyltransferase and uses thereof.

  本发明公开了一种固定化环脂族肽酰基转移酶及其制备方法和用途。环脂族肽酰基转移酶固定在载体上；环脂族肽酰基转移酶来源于天然或人工突变体或其变异体，也可以通过导入外来环酰基转移酶基因并转化后获得；载体的材料选自无机载体或聚丙烯树脂载体。本发明还公开了固定化环脂肽酰基转移酶的制备方法及其用途。
• PROCESS FOR PURIFYING CYCLOLIPOPEPTIDE COMPOUNDS OR THE SALTS THEREOF
  申请人：Zhang Zhaoli

  公开号：US20130296529A1

  公开（公告）日：2013-11-07

  A method for purifying a cyclic lipopepteide or a salt thereof is provided. The method comprises the steps: (1) extracting a fermentation broth containing a compound of formula I or a salt thereof, to obtain an extract 1 after filtration or centrifugation; (2) diluting or concentrating the extract 1 under vacuum to decrease the content of the organic solvent, to obtain an extract 2; (3) loading the extract 2 onto a macroporous absorption resin; (4) washing the macroporpous adsorption resin with water, an organic solvent, or a mixture of water and an organic solvent as a washing solution; and (5) eluting the compound of formula I off from the macroporous adsorption resin with water, an organic solvent, or a mixture of water and an organic solvent as a washing solution as an eluant. Compared with the prior art, the purification method has the advantages that fewer organic solvent is used, no silica gel is used, the harm to the environment is less, and the purity of the collected compound of formula I is improved.
• US7199248B2
  申请人：——

  公开号：US7199248B2

  公开（公告）日：2007-04-03
• US8877777B2
  申请人：——

  公开号：US8877777B2

  公开（公告）日：2014-11-04
• [EN] INTERMEDIATES AND PROCESSES TO PREPARE MICAFUNGIN<br/>[FR] PRODUITS INTERMÉDIAIRES ET PROCÉDÉS DE PRÉPARATION DE MICAFUNGINE
  申请人：ALAPARTHI LAKSHMI PRASAD

  公开号：WO2016056023A2

  公开（公告）日：2016-04-14

  The present invention relates to active esters of compound of Formula I-A and Formula I-B which are used as key intermediates in the synthesis of Micafungin, an antifungal agent and process of preparation of said active esters. The invention also relates to process of preparing Micafungin from said active esters.