Pro-Ile-Gly

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Pro-Ile-Gly
• 英文别名: 2-[[(2S,3S)-3-methyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]pentanoyl]amino]acetic acid
• 化学式: C₁₃H₂₃N₃O₄
• 分子量: 285.34
• InChiKey: XYHMFGGWNOFUOU-QXEWZRGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• EPITHELIAL CELL GROWTH PROMOTER
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP1741719A1

  公开（公告）日：2007-01-10

  It is intended to provide a novel oligopeptide which can be relatively easily produced, has not only a hair growth-stimulating effect but also an effect of promoting the growth of epithelial cells (for example, skin regeneration) and can easily pass through the horny layer to thereby reach the desired target cells in which its effects are to be exerted. Namely, water-soluble oligopeptides containing a proryl isoleucyl glycyl unit or an isoleucyl glycyl serine unit and having from 3 to 7 amino acids and water-soluble salts thereof.

  本发明旨在提供一种新型低聚肽，这种低聚肽比较容易生产，不仅具有刺激毛发生长的作用，而且还具有促进上皮细胞生长（例如，皮肤再生）的作用，并且可以很容易地穿过角质层，从而到达需要发挥其作用的靶细胞。即，含有一个异亮氨酰甘氨酰单位或一个异亮氨酰甘氨酰丝氨酸单位，并具有 3 至 7 个氨基酸的水溶性寡肽及其水溶性盐。
• COMPOSITION CONTAINING THERMOSENSITIVE GEL AND OLIGOPEPTIDE, AND USE THEREOF
  申请人：International Frontier Technology Laboratory Inc.

  公开号：EP4026841A1

  公开（公告）日：2022-07-13

  The present disclosure relates to a composition which can promote cell proliferation, can be used for coating a wound or the like and culturing or preserving cells and tissues, and comprises a polymer compound. The composition of the present disclosure comprises a polymer compound which has a sol-gel transition temperature, reversibly transforms to a sol state at a temperature lower than the transition temperature, and comprises hydrophobic and hydrophilic portions and an oligopeptide having a cell proliferation function.

  本公开涉及一种可促进细胞增殖的组合物，该组合物可用于涂覆伤口或类似物，以及培养或保存细胞和组织，并由聚合物化合物组成。本公开的组合物包括一种聚合物化合物，它具有溶胶-凝胶转变温度，在低于转变温度的温度下可逆地转变为溶胶态，并包括疏水和亲水部分以及具有细胞增殖功能的寡肽。
• Epithelial cell growth promoter
  申请人：Patent Technology Development Inc.

  公开号：EP1741719B1

  公开（公告）日：2015-02-25
• Epithelial Cell Growth Promoter
  申请人：Oka Syuichi

  公开号：US20070213276A1

  公开（公告）日：2007-09-13

  It is intended to provide a novel oligopeptide which can be relatively easily produced, has not only a hair growth-stimulating effect but also an effect of promoting the growth of epithelial cells (for example, skin regeneration) and can easily pass through the horny layer to thereby reach the desired target cells in which its effects are to be exerted. Namely, water-soluble oligopeptides containing a proryl isoleucyl glycyl unit or an isoleucyl glycyl serine unit and having from 3 to 7 amino acids and water-soluble salts thereof.
• Uv-Induced Dermatitis Inhibitor and Atopic Dermatitis Inhibitor
  申请人：Oka Syuichi

  公开号：US20090215702A1

  公开（公告）日：2009-08-27

  At least one substance selected from the group consisting of a water-soluble peptide comprising at least one unit selected from the group consisting of an isoleucylglycylseryl unit, a prolylisoleucylglycylseryl unit, a glycylprolylisoleucylseryl unit, a glycylprolylisoleucylglycylthreonyl unit, a prolylisoleucylglycyl unit and a glycylprolylisoleucylglycyl unit and a water-soluble salt thereof can be used as an UV-induced dermatitis inhibitor or atopic dermatitis inhibitor.