4-[2-[4-(2-Ethoxy-3-hydroxypropyl)phenoxy]ethyl]benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[2-[4-(2-Ethoxy-3-hydroxypropyl)phenoxy]ethyl]benzonitrile
• 化学式: C₂₀H₂₃NO₃
• 分子量: 325.4
• InChiKey: FHURGCAPCFGZJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  62.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Substituted aralkyl derivatives
  申请人：Lohray Braj B.

  公开号：US20090275565A1

  公开（公告）日：2009-11-05

  The present invention relates to novel substituted aralkyl derivatives of the general formula (I) and (IIIa), their derivatives, their analogs, their tautomeric forms, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, pharmaceutical compositions containing them, use of these compounds in medicine and the intermediates involved in their preparation.

  本发明涉及一种新的通式(I)和(IIIa)的取代芳基烷基衍生物，它们的衍生物、类似物、互变异构体、药学上可接受的盐、药学上可接受的溶剂化合物、含有它们的药物组合物、这些化合物在医学上的应用以及其制备中所涉及的中间体。
• NEW PHENALKYLOXY-PHENYL DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP1237857B1

  公开（公告）日：2004-06-30
• SUBSTITUTED ARALKYL DERIVATIVES
  申请人：CADILA HEALTHCARE LIMITED

  公开号：EP1569916B1

  公开（公告）日：2009-01-07
• US6630509B2
  申请人：——

  公开号：US6630509B2

  公开（公告）日：2003-10-07
• [EN] NEW PHENALKYLOXY-PHENYL DERIVATIVES<br/>[FR] NOUVEAUX DERIVES PHENALKYLOXY-PHENYLE
  申请人：ASTRAZENECA AB

  公开号：WO2001040170A1

  公开（公告）日：2001-06-07

  The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I) and analogs, to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.