3-{3-[2-(3-Hydroxy-oct-1-ynyl)-5-oxo-pyrrolidin-1-yl]-propylsulfanyl}-propionic acid | 492472-07-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-{3-[2-(3-Hydroxy-oct-1-ynyl)-5-oxo-pyrrolidin-1-yl]-propylsulfanyl}-propionic acid
• 英文别名: 3-[3-[2-(3-Hydroxyoct-1-ynyl)-5-oxopyrrolidin-1-yl]propylsulfanyl]propanoic acid
• CAS: 492472-07-8
• 化学式: C₁₈H₂₉NO₄S
• 分子量: 355.499
• InChiKey: UYELTLRMMKVCOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 2-pyrrolidone derivatives as prostanoid agonists
  申请人：——

  公开号：US20030064964A1

  公开（公告）日：2003-04-03

  This invention relates to 8-aza prostanoid analogs which are generally EP 4 receptor agonists and are represented by Formula I: 1 wherein Q, B, X, J, Z, A and R 1 -R 6 are as defined, their synthesis and use for treatment of osteoporosis and increasing bone density.

  这项发明涉及一种通常为EP4受体激动剂的8-aza前列腺素类似物，其由以下式I表示：其中Q、B、X、J、Z、A和R1-R6如定义，它们的合成和用于治疗骨质疏松症和增加骨密度。
• 2 PYRROLIDONE DERIVATIVES AS PROSTANOID AGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1408961A1

  公开（公告）日：2004-04-21
• US6849657B2
  申请人：——

  公开号：US6849657B2

  公开（公告）日：2005-02-01
• [EN] 2 PYRROLIDONE DERIVATIVES AS PROSTANOID AGONISTS<br/>[FR] DERIVES DE PYRROLIDONE COMME ANTAGONISTES DE PROSTANOIDE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003007941A1

  公开（公告）日：2003-01-30

  This invention relates to 8-aza prostanoid analogs which are generally EP4 receptor agonists and are represented by Formula I: wherein Q, B, X, I, Z, A and R1-R6 are as defined in the description, their synthesis and use for treatment of osteoporosis and increasing bone density.