2-(2,3-dihydro-1H-8-oxa-cyclopenta[a]indene-6-sulfonylamino)-2-methylpropionic acid | 326499-83-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2,3-dihydro-1H-8-oxa-cyclopenta[a]indene-6-sulfonylamino)-2-methylpropionic acid
• 英文别名: 2-(2,3-dihydro-1H-cyclopenta[b][1]benzofuran-6-ylsulfonylamino)-2-methylpropanoic acid
• CAS: 326499-83-6
• 化学式: C₁₅H₁₇NO₅S
• 分子量: 323.37
• InChiKey: OMAOAPOTTIUPNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• HYDROXAMIC ACID COMPOUNDS USEFUL AS MATRIX METALLOPROTEINASE INHIBITORS
  申请人：Warner-Lambert Company LLC

  公开号：EP1210326B1

  公开（公告）日：2004-02-25
• US6677355B1
  申请人：——

  公开号：US6677355B1

  公开（公告）日：2004-01-13
• [EN] HYDROXAMIC ACID COMPOUNDS USEFUL AS MATRIX METALLOPROTEINASE INHIBITORS<br/>[FR] COMPOSES D'ACIDE HYDROXAMIQUE UTILES COMME INHIBITEURS DE METALLOPROTEINASES MATRICIELLES
  申请人：WARNER LAMBERT CO

  公开号：WO2001012592A2

  公开（公告）日：2001-02-22

  Compounds of formula (I), are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also disclosed are methods for the preparation of such compounds, pharmaceutical compositions including the same, and methods of treating diseases in which matrix metalloproteinases are involved including multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurysm, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, osteoporosis, rheumatoid or osteoarthritis, renal disease, left ventricular dilation, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.