(5S,6R,7E,9E,11Z,13E,15R)-5,6,15-trihydroxy-16,16-dimethylicosa-7,9,11,13-tetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5S,6R,7E,9E,11Z,13E,15R)-5,6,15-trihydroxy-16,16-dimethylicosa-7,9,11,13-tetraenoic acid
• 化学式: C₂₂H₃₆O₅
• 分子量: 380.5
• InChiKey: NDRKENRGVUHDLB-LRRYGRKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Lipoxin compounds
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：EP2107050A1

  公开（公告）日：2009-10-07

  Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. These small molecules are useful for treating vasoconstrictive, inflammatory, myeloid suppressive, cardiovascular, and gastrointestinal diseases.

  本研究公开了具有天然脂毒素活性位点但组织半衰期更长的化合物。这些小分子化合物可用于治疗血管收缩性疾病、炎症性疾病、骨髓抑制性疾病、心血管疾病和胃肠道疾病。
• Lipoxin compounds and their use in treating cell proliferative disorders
  申请人：THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

  公开号：EP1201639B1

  公开（公告）日：2008-08-13
• LIPOXIN COMPOUNDS WITH PROLONGED HALF-LIFE
  申请人：THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

  公开号：EP0703897B1

  公开（公告）日：2008-08-20
• Modulation of Inflammation Related to Columnar Epithelia
  申请人：Madara L. James

  公开号：US20080064660A1

  公开（公告）日：2008-03-13

  This invention provides pharmaceutical compositions containing lipoxin compounds and therapeutic uses for the compounds in treating or preventing a disease or condition associated with columnar epithelial inflammation. The invention also discloses methods for screening for compounds useful in preventing columnar epithelial inflammation.
• Lipoxin Compounds and Their use in Treating Cell Proliferative Disorders
  申请人：Serhan Charles N.

  公开号：US20090270498A1

  公开（公告）日：2009-10-29

  Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.