5-chloro-6-(2-chloro-6-fluorophenyl)-7-(4-methyl-piperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-chloro-6-(2-chloro-6-fluorophenyl)-7-(4-methyl-piperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidine
• 英文别名: 5-chloro-6-(2-chloro-6-fluorophenyl)-7-(4-methylpiperid-1-yl)-[1,2,4]triazolo[1.5-a]pyrimidine；5-chloro-6-(2-chloro-6-fluorophenyl)-7-(4-methyl-1-piperidinyl)[1,2,4]triazolo[1,5-a]pyrimidine；5-Chloro-6-(2-chloro-6-fluorophenyl)-7-(4-methylpiperidin-1-yl)-[1,2,4]-triazolo[1,5-alpha]pyrimidine；5-chloro-6-(2-chloro-6-fluorophenyl)-7-(4-methylpiperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidine
• 化学式: C₁₇H₁₆Cl₂FN₅
• 分子量: 380.252
• InChiKey: BPJQBJUREDQRRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  46.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-chloro-6-(2-chloro-6-fluorophenyl)-7-(4-methyl-piperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidine 、 、 sodium methylate 、 甲醇 在 二氯甲烷 、 水 、 silica gel 作用下， 反应 16.0h， 以gave 4.2 g of the title compound of mp. 182° C.的产率得到5-Methoxy-6-(2-chloro-6-fluorophenyl)-7-isopropylamino-[1,2,4]-triazolo[1,5-alpha]pyrimidine
  参考文献：
  名称：

  6-(2-chloro-6-fluoro-phenyl)-triazolopyrimidines

  摘要：

  化学式为(I)的6-(2-氯-6-氟苯基)-三唑嘧啶，其中R1和R2分别表示氢或烷基，烯基，炔基，烷二烯基或卤代烷基，环烷基，双环烷基，苯基，萘基或含有1-4个氮原子或1-3个氮原子和1个硫或氧原子的5或6元杂环基，或含有1-4个氮原子或1-3个氮原子和1个硫或氧原子的5或6元杂环芳基，或者R1和R2基团可以是未取代的或部分或完全卤代的，或者可以按照描述中的定义取代。R1和R2与相邻的氮原子一起表示一个5或6元杂环环，其中包含1-4个氮原子或1-3个氮原子和1个硫或氧原子，可以被取代；X是氰基，烷氧基，卤代烷氧基或烯基氧基；它们的制备方法，含有它们的组合物以及用于防治植物病原真菌的用途。

  公开号：

  US07071334B2

文献信息

• Substituted-triazolopyrimidines as anticancer agents
  申请人：American Home Products Corporation

  公开号：US20020068744A1

  公开（公告）日：2002-06-06

  The invention provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.

  该发明提供了一种治疗或抑制哺乳动物体内癌症肿瘤细胞及相关疾病的方法，包括向该哺乳动物体内施用有效量的取代三唑吡啶衍生物或其药学上可接受的盐，并进一步提供了一种通过与微管蛋白和微管相互作用并促进微管聚合的方法，治疗或抑制哺乳动物体内癌症肿瘤细胞及相关疾病，包括向该哺乳动物体内施用有效量的取代三唑吡啶衍生物或其药学上可接受的盐。
• Synergistic Active Compound Combinations Comprising Phenyltriazoles
  申请人：Andersch Wolfram

  公开号：US20110166109A1

  公开（公告）日：2011-07-07

  The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) in which R 1 and R 2 have the meanings given in the description. and at least one further known active compound from groups (2) to (27) listed in the description, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids and also phytopathogenic fungi.

  本发明涉及一种新型活性化合物组合，首先包括至少一种已知的式(I)化合物，其中R1和R2具有描述中给出的含义，并且至少包括描述中列出的第(2)至第(27)组的另一种已知活性化合物，这些组合非常适用于控制动物害虫，如昆虫和不受欢迎的螨虫，以及植物病原真菌。
• Synergistic Combinations Of Active Ingredients
  申请人：Jeschke Peter

  公开号：US20120035050A1

  公开（公告）日：2012-02-09

  The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) in which R 1 and A have the meanings given in the description and, secondly, at least one further known active compound from groups (2) to (27) listed in the description, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids and also phytopathogenic fungi.

  本发明涉及一种新颖的活性化合物组合，首先包括至少一种已知的化合物，其化学式为(I)，其中R1和A具有描述中给出的含义；其次，还包括至少一种来自描述中列出的(2)至(27)组的进一步已知活性化合物，这些组合非常适用于控制动物害虫，如昆虫和不受欢迎的螨虫，以及植物病原真菌。
• Emulsifiable concentrate containing one or more pesticides
  申请人：American Cyanamid Company

  公开号：EP0933025A1

  公开（公告）日：1999-08-04

  The novel EC containing at least one pesticidal active ingredient, in particular a commercially available fungicide or herbicide, a solvent which essentially consists of one or more esters of plant oils, a cosolvent selected from the class of water-miscible polar aprotic solvents, and an emulsifying surfactant system forming an oil in water emulsion when the formulation is added to water is very suitable for combating pests or diseases caused by pests at a locus by treating the locus with a composition obtained from emulsifying the said EC in water.

  新型乳油含有至少一种杀虫活性成分，特别是市售的杀真菌剂或除草剂，一种主要由一种或多种植物油酯类组成的溶剂，一种选自水混溶极性烷基溶剂的助溶剂，以及一种乳化表面活性剂体系，当制剂加入水中时会形成水包油乳液。
• Fungicidal mixtures
  申请人：American Cyanamid Company

  公开号：EP0988790A1

  公开（公告）日：2000-03-29

  Fungicidal compositions comprising an acceptable carrier and/or surface active agent and synergistically effective amounts of (a) at least one azolopyrimidine of formula I in which R1, R2, L1, L2 and L3 have the meaning given in claim 1; and (b) at least one fungicidal active ingredient selected from benomyl, carboxin, captan, chlorothalonil, copper oxychloride, cyprodinil, dimethomorph, dithianon, dodine, famoxadone, fenhexamid, fenpiclonil, fenpropimorph, fluazinam, mancozeb, metalaxyl, pyrimethanil, quinoxifen, sulfur, triforine, vinclozolin, a fungicidal triazole derivative, and a synthetic strobilurine derivative. The invention also provides a method of controlling the growth of phytopathogenic fungi at a locus by applying synergistically effective amounts of at least one azolopyrimidine of formula I and at least one fungicidal active ingredient (b) to the locus.

  杀菌组合物，包括可接受的载体和/或表面活性剂以及协同有效量的以下物质 (a) 至少一种式 I 的偶氮嘧啶 其中 R1、R2、L1、L2 和 L3 具有权利要求 1 所述含义；以及 (b) 至少一种杀菌活性成分，选自苯菌灵、虫螨腈、克菌丹、百菌清、氧氯化铜、霜脲氰、二甲吗啉、噻虫嗪、多丁、霜脲氰、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑fenpiclonil、fenpropimorph、fluazinam、mancozeb、metalaxyl、pyrimethanil、quinoxifen、sulfur、triforine、vinclozolin、一种杀真菌的三唑衍生物，以及一种合成的strobilurine衍生物。本发明还提供了一种控制植物病原真菌在基因座上生长的方法，即在基因座上施用至少一种式 I 的唑嘧啶和至少一种杀真菌活性成分 (b) 的协同有效量。