(6E,8E)-5-acetyloxy-2-amino-3-hydroxy-2-(hydroxymethyl)icosa-6,8-dienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (6E,8E)-5-acetyloxy-2-amino-3-hydroxy-2-(hydroxymethyl)icosa-6,8-dienoic acid
• 化学式: C₂₃H₄₁NO₆
• 分子量: 427.6
• InChiKey: NWCKLZQUWFMRQV-ZBMVRHCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  30
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Small molecule immunopotentiators and assays for their detection
  申请人：Valiante Nicholas

  公开号：US20110104186A1

  公开（公告）日：2011-05-05

  The invention provides immunostimulatory compositions comprising a small molecule immuno-potentiator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma. In a further aspect, the invention relates generally to methods of screening for small molecule immuno-modulatory compositions.