(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid;2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid;2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
• 化学式: C51H72N4O9
• 分子量: 885.1
• InChiKey: HWDPVPHFEFAMOS-QSYPGBKBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.87
• 重原子数：
  64
• 可旋转键数：
  23
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  160
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Combination drug therapy for treating hypertension
  申请人：Pepine J. Carl

  公开号：US20050032784A1

  公开（公告）日：2005-02-10

  Disclosed are compositions and methods for treating, preventing, and ameliorating hypertension, especially in patients with coronary artery disease, patients at risk for strokes, patients with renal disease, and patients with diabetes or at risk for diabetes. The compositions and methods relate to a combination therapy using three classes of anti-hypertension drugs, including calcium antagonists, angiotensin-converting-enzyme inhibitors, and diuretics. The preferred drugs in the compositions and methods are verapamil, trandolapril, and hydrochlorothiazide.

  本发明公开了用于治疗、预防和改善高血压的组合物和方法，尤其适用于冠心病患者、有中风风险的患者、肾病患者和糖尿病患者或有糖尿病风险的患者。这些组合物和方法涉及使用三类抗高血压药物的联合疗法，包括钙拮抗剂、血管紧张素转换酶抑制剂和利尿剂。组合物和方法中的首选药物是维拉帕米、曲多普利和氢氯噻嗪。
• EP1610775A2
  申请人：——

  公开号：EP1610775A2

  公开（公告）日：2006-01-04
• [EN] COMBINATION DRUG THERAPY FOR TREATING HYPERTENSION<br/>[FR] TRAITEMENT DE L'HYPERTENSION PAR ASSOCIATION DE MEDICAMENTS
  申请人：UNIV FLORIDA

  公开号：WO2004087132A2

  公开（公告）日：2004-10-14

  Disclosed are compositions and methods for treating, preventing, and ameliorating hypertension, especially in patients with coronary artery disease, patients at risk for strokes, patients with renal disease, and patients with diabetes or at risk for diabetes. The compositions and methods relate to a combination therapy using three classes of anti-hypertension drugs, including calcium antagonists, angiotensin-converting-enzyme inhibitors, and diuretics. The preferred drugs in the compositions and methods are verapamil, trandolapril, and hydrochlorothiazide.