N-octyldecan-1-aminium chloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-octyldecan-1-aminium chloride
• 英文别名: N-octyldecan-1-amine;hydrochloride
• 化学式: C₁₈H₃₉N*ClH
• 分子量: 305.975
• InChiKey: KIZODRWQLXVXLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.06
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  16.6
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-octyldecan-1-aminium chloride 、 (S)-2,6-二叔丁氧羰基氨基己酸 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.58h， 以79%的产率得到Boc-Lys(Boc)-N-octylaminodecane
  参考文献：
  名称：

  设计简单的脂质赖氨酸：分叉影响选择性的抗菌活性。

  摘要：

  在阻止抗菌素耐药性的全球努力中，脂肽是一类重要的抗菌剂，尤其是针对革兰氏阴性感染的抗菌剂。为了避免其合成复杂性，我们设计了仅涉及一个氨基酸和两个脂质尾巴的简单膜活性剂。在本文中，我们显示使用两个短脂质尾而不是单个长脂质尾显着增加了选择性抗菌活性。这项研究产生了几种选择性的抗菌化合物，并使用活性最高的化合物对此类化合物的性质进行了研究。荧光光谱研究揭示了代表性化合物引起细菌细胞膜去极化和透化的能力。化合物的这种膜活性性质赋予其对持久性细胞，生物膜和浮游细胞的优异活性。局部应用该化合物可减轻小鼠因烧伤引起的细菌负担鲍曼不动杆菌。我们期望本文所述的设计原理将指导几种具有临床重要性的抗微生物剂的开发。

  DOI：

  10.1002/cmdc.201600400
• 作为产物：
  描述：

  癸醛 、 辛胺 在 sodium tetrahydroborate 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 6.0h， 以62%的产率得到N-octyldecan-1-aminium chloride
  参考文献：
  名称：

  [EN] ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND APPLICATIONS THEREOF
  [FR] COMPOSÉS ANTIMICROBIENS, LEUR SYNTHÈSE ET LEURS APPLICATIONS

  摘要：

  本公开涉及药物化学领域，更具体地涉及抗菌化合物的开发。该公开涉及合成和表征包含芳香基团或脂肪基团、烷基胺和氨基酸基团的化合物，其中这些化合物对各种对药物敏感和耐药病原微生物表现出抗菌活性。

  公开号：

  WO2014097178A1

文献信息

• ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND APPLICATIONS THEREOF
  申请人：JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESARCH

  公开号：US20150329478A1

  公开（公告）日：2015-11-19

  The present disclosure relates to the field of medicinal chemistry and more particularly to the development of antimicrobial compounds. The disclosure relates to the synthesis and characterization of compounds comprising aromatic radical or an aliphatic radical, an alkyl amine and amino acid moiety wherein said compounds exhibit antimicrobial activity against various drug-sensitive and drug-resistant pathogenic 10 microorganisms.

  本公开涉及药物化学领域，更具体地涉及抗微生物化合物的开发。本公开涉及合成和表征包含芳基或脂肪基、烷基胺和氨基酸基团的化合物，其中所述化合物对各种药物敏感和耐药的致病微生物表现出抗微生物活性。
• Hard surface cleaning compositions, premoistened wipes, methods of use, and articles comprising said compositions
  申请人：The Procter and Gamble Company

  公开号：EP1661503A2

  公开（公告）日：2006-05-31

  The present invention provides preferred, preferably liquid, hard surface cleaning compositions, compositions with cleaning liquid composition on a substrate, compositions used with absorbent pads and implements and devices for making the process of cleaning hard surfaces and/or maintaining their appearance and hygiene easier and more effective. These compositions, along with specific instructions for use are advantageous for removal of and/or prevention of buildup of soils commonly encountered on floors, glass surfaces, counters, walls, showers and/or tubs, said compositions comprising hydrophilic polymers to render the cleaned surface hydrophilic and to improve the appearance when the surface is either not rinsed, or when the composition is incompletely removed, specific surfactant, preferably surfactant selected to minimize spotting/filming, optionally specific organic cleaning solvents to provide cleaning and wetting particularly in applications where levels of non-volatiles need to be minimized, and, optionally, anti-bacterial agents for preserving or surface activity and optionally perfumes for aesthetics.

  本发明提供了优选的（最好是液态的）硬表面清洁组合物、基质上含有清洁液体组合物的组合物、与吸水垫和工具及装置一起使用的组合物，用于使清洁硬表面和/或保持其外观和卫生的过程变得更简单、更有效。这些组合物以及具体的使用说明有利于清除和/或防止地板、玻璃表面、台面、墙壁、淋浴间和/或浴缸上常见的污垢堆积，所述组合物包括亲水性聚合物，可使清洁后的表面具有亲水性，并在未冲洗表面时改善外观、特定的表面活性剂，最好是选择表面活性剂，以尽量减少斑点/成膜；可选择特定的有机清洁溶剂，以提供清洁和润湿效果，特别是在需要尽量减少非挥发性物质含量的应用中；可选择抗菌剂，以保持表面活性；可选择香料，以增加美感。
• Hard surface cleaning compositions, premoistened wipes, methods of use, and articles comprising said compositions or wipes and instructions for use resulting in easier cleaning and maintenance, improved surface appearance and/or hygiene under stress conditions such as no-rinse
  申请人：The Procter and Gamble Company

  公开号：EP2036481A2

  公开（公告）日：2009-03-18

  The present invention provides preferred, preferably liquid, hard surface cleaning compositions, compositions with cleaning liquid composition on a substrate, compositions used with absorbent pads and implements and devices for making the process of cleaning hard surfaces and/or maintaining their appearance and hygiene easier and more effective. These compositions, along with specific instructions for use are advantageous for removal of and/or prevention of buildup of soils commonly encountered on floors, glass surfaces, counters, walls, showers and/or tubs, said compositions comprising hydrophilic polymers to render the cleaned surface hydrophilic and to improve the appearance when the surface is either not rinsed, or when the composition is incompletely removed, specific surfactant, preferably surfactant selected to minimize spotting/filming, optionally specific organic cleaning solvents to provide cleaning and wetting particularly in applications where levels of non-volatiles need to be minimized, and, optionally, anti-bacterial agents for preserving or surface activity and optionally perfumes for aesthetics.

  本发明提供了优选的（最好是液态的）硬表面清洁组合物、基质上含有清洁液体组合物的组合物、与吸水垫和工具及装置一起使用的组合物，用于使清洁硬表面和/或保持其外观和卫生的过程变得更简单、更有效。这些组合物以及具体的使用说明有利于清除和/或防止地板、玻璃表面、台面、墙壁、淋浴间和/或浴缸上常见的污垢堆积，所述组合物包括亲水性聚合物，可使清洁后的表面具有亲水性，并在未冲洗表面时改善外观、特定的表面活性剂，最好是选择表面活性剂，以尽量减少斑点/成膜；可选择特定的有机清洁溶剂，以提供清洁和润湿效果，特别是在需要尽量减少非挥发性物质含量的应用中；可选择抗菌剂，以保持表面活性；可选择香料，以增加美感。
• Hard surface cleaning compositions and wipes
  申请人：——

  公开号：US20040127378A1

  公开（公告）日：2004-07-01

  The present invention provides preferred, preferably liquid, hard surface cleaning compositions, compositions with cleaning liquid composition on a substrate, compositions used with absorbent pads and implements and devices for making the process of cleaning hard surfaces and/or maintaining their appearance and hygiene easier and more effective. These compositions, along with specific instructions for use are advantageous for removal of and/or prevention of buildup of soils commonly encountered on floors, glass surfaces, counters, walls, showers and/or tubs, said compositions comprising hydrophilic polymers to render the cleaned surface hydrophilic and to improve the appearance when the surface is either not rinsed, or when the composition is incompletely removed, specific surfactant, preferably surfactant selected to minimize spotting/filming, optionally specific organic cleaning solvents to provide cleaning and wetting particularly in applications where levels of non-volatiles need to be minimized, and, optionally, anti-bacterial agents for preserving or surface activity and optionally perfumes for aesthetics.

  本发明提供了优选的（最好是液态的）硬表面清洁组合物、基质上含有清洁液体组合物的组合物、与吸水垫和工具及装置一起使用的组合物，用于使清洁硬表面和/或保持其外观和卫生的过程变得更简单、更有效。这些组合物以及具体的使用说明有利于清除和/或防止地板、玻璃表面、台面、墙壁、淋浴间和/或浴缸上常见的污垢堆积，所述组合物包括亲水性聚合物，可使清洁后的表面具有亲水性，并在未冲洗表面时改善外观、特定的表面活性剂，最好是选择表面活性剂，以尽量减少斑点/成膜；可选择特定的有机清洁溶剂，以提供清洁和润湿效果，特别是在需要尽量减少非挥发性物质含量的应用中；可选择抗菌剂，以保持表面活性；可选择香料，以增加美感。
• HARD SURFACE CLEANING COMPOSITIONS
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1290121A2

  公开（公告）日：2003-03-12