3-Cyano-2-nitro-5-sulfanylidenecyclohexa-1,3-diene-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 3-Cyano-2-nitro-5-sulfanylidenecyclohexa-1,3-diene-1-carboxylic acid
• 化学式: C8H4N2O4S
• 分子量: 224.2
• InChiKey: XTXMZBKTNKZEAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• High-throughput single molecule protein identification
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US10466248B2

  公开（公告）日：2019-11-05

  The present invention is methods and assays for identifying single proteins from a sample, without the use of affinity reagents. The methods and assays combine endopeptidase-based component of conventional peptide mapping with single molecule labeling and a microreactor array platform. The invention also includes kits for performing the methods and assays.

  本发明是在不使用亲和试剂的情况下从样品中鉴定单个蛋白质的方法和检测方法。这些方法和检测方法将传统肽图谱中基于内肽酶的部分与单分子标记和微反应器阵列平台相结合。本发明还包括用于执行这些方法和检测的试剂盒。
• HIGH-THROUGHPUT SINGLE MOLECULE PROTEIN IDENTIFICATION
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20160238612A1

  公开（公告）日：2016-08-18

  The present invention is methods and assays for identifying single proteins from a sample, without the use of affinity reagents. The methods and assays combine endopeptidase-based component of conventional peptide mapping with single molecule labeling and a microreactor array platform. The invention also includes kits for performing the methods and assays.
• [EN] HIGH-THROUGHPUT SINGLE MOLECULE PROTEIN IDENTIFICATION<br/>[FR] IDENTIFICATION À HAUT DÉBIT DE PROTÉINES MOLÉCULAIRES INDIVIDUELLES
  申请人：UNIV COLUMBIA

  公开号：WO2015042506A1

  公开（公告）日：2015-03-26

  The present invention is methods and assays for identifying single proteins from a sample, without the use of affinity reagents. The methods and assays combine endopeptidase-based component of conventional peptide mapping with single molecule labeling and a microreactor array platform. The invention also includes kits for performing the methods and assays.