(2R)-2-amino-2-methyl-4-[4-(3-phenylpropoxy)phenyl]butan-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2R)-2-amino-2-methyl-4-[4-(3-phenylpropoxy)phenyl]butan-1-ol
• 化学式: C₂₀H₂₇NO₂
• 分子量: 313.4
• InChiKey: CETMIEJVKCOWKS-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES<br/>[FR] DERIVES DE 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RENINE DANS LE TRAITEMENT DE L'HYPERTENSION, DE MALADIES CARDIOVASCULAIRES OU RENALES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2003093267A1

  公开（公告）日：2003-11-13

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.

  该发明涉及新型3,9-二氮杂双环[3.3.1]壬烯衍生物（I）及相关化合物，以及它们作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，尤其是它们作为肾素抑制剂的用途。
• 2-Amino-propanol derivatives
  申请人：——

  公开号：US20040147490A1

  公开（公告）日：2004-07-29

  Compounds of formula (i), wherein m, R, R 1 , and R 3 to R 6 are as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compounds have interesting properties, e.g. immunosuppressive properties. 1

  式子为(i)的化合物，其中m，R，R1和R3到R6如规范所定义，m为1，2或3，X为O或直接键，并且相应的未磷酸化化合物具有有趣的性质，例如免疫抑制性质。
• CYCLIC AMINE DERIVATIVE CONTAINING PPAR REGULATOR
  申请人：Sankyo Company, Limited

  公开号：EP1915994A1

  公开（公告）日：2008-04-30

  [Object] To provide a pharmaceutical composition which is excellent as a medicament for prevention or treatment of diseases relating to immune action such as autoimmune diseases. [Means for Solution] A pharmaceutical composition comprising 1 or 2 or more selected from PPAR regulators and 1 or 2 or more selected from the group consisting of amino alcohol derivatives of the general formula (I): [wherein R1 and R2 are the same or different, and each represents a hydrogen atom or the like; R3 represents a C1-C6 alkyl group or a hydroxymethyl group; R4 represents a hydrogen atom, a C1-C6 alkyl group or the like; R5 represents a phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydrogen atom, a halogen atom, a cyano group, a C1-C6 alkyl group or the like; X represents a vinylene group (CH=CH group), an oxygen atom or the like; Y represents a single bond, an oxygen atom or the like; Z represents a single bond, a C1-C8 alkylene group or the like; n represents an integer of 2 or 3]; and pharmacologically acceptable salt thereof.

  [目的]提供一种药物组合物，该药物组合物是预防或治疗自身免疫性疾病等与免疫作用有关的疾病的优良药物。 [解决方法］ 一种药物组合物，包括 1或2种或更多选自PPAR调节剂和 1或2个或2个以上选自通式(I)的氨基醇衍生物组成的组： 其中 R1 和 R2 相同或不同，各自代表氢原子或类似物； R3 代表 C1-C6 烷基或羟甲基； R4 代表氢原子、C1-C6 烷基或类似物； R5 代表被 1 至 3 个选自氢原子、卤素原子、氰基、C1-C6 烷基或类似物组成的取代基取代的苯基；X 代表乙烯基（CH=CH 基）、氧原子或类似物； Y 代表单键、氧原子或类似物； Z 代表单键、C1-C8 亚烷基或类似物； n 代表 2 或 3 的整数]；以及 其药理学上可接受的盐。
• 2-AMINO-PROPANOL DERIVATIVES
  申请人：Novartis AG

  公开号：EP1377593A2

  公开（公告）日：2004-01-07
• 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP1501830A1

  公开（公告）日：2005-02-02