2-[(2Z,5Z,9R,11Z)-9-hydroxyheptadeca-2,5,11-trienoxy]acetic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-[(2Z,5Z,9R,11Z)-9-hydroxyheptadeca-2,5,11-trienoxy]acetic acid
• 化学式: C₁₉H₃₂O₄
• 分子量: 324.5
• InChiKey: PFMJRCGSXRVEPZ-HMWHDKFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 12-HETrE analogs and methods of use thereof
  申请人：——

  公开号：US20020151734A1

  公开（公告）日：2002-10-17

  The present invention to 12-HETrE analogs which are agonists and antagonists of 12-HETrE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for treating inflammatory conditions, neovascularization, tumor growth, cancer, ischemic cardiovascular diseases, and ocular conditions.

  本发明涉及12-HETrE类似物，其为12-HETrE的激动剂和拮抗剂。这些组合物可以制成药学上可接受的制剂。本发明还包括用于治疗炎症、新生血管形成、肿瘤生长、癌症、缺血性心血管疾病和眼部疾病的方法和产品。
• [EN] 12-HETRE ANALOGS AND METHODS OF USE THEREOF<br/>[FR] ANALOGUES 12-HETRE ET LEURS PROCEDES D'UTILISATION
  申请人：NEW YORK MEDICAL COLLEGE

  公开号：WO2002059072A2

  公开（公告）日：2002-08-01

  The present invention to 12-HETrE analogs which are agonists and antagonists of 12-HETrE. The compositions may be formulated in pharmaceutically acceptable formulations. The inventions also includes methods and products for treating inflammatory conditions, neovascularization, tumor growth, cancer, ischemic cardiovascular diseases, and ocular conditions.