3,3-difluoro-1-phenyltridec-1-yn-4-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-difluoro-1-phenyltridec-1-yn-4-ol
• 英文别名: 3,3-Difluoro-1-phenyltridec-1-yn-4-ol
• 化学式: C₁₉H₂₆F₂O
• 分子量: 308.412
• InChiKey: GLFDDZUIMMJHJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  癸醛 、 bromodifluoromethylphenylacetylene 在 indium(III) chloride 、 tin 作用下， 以 水 为溶剂， 反应 12.0h， 以61%的产率得到3,3-difluoro-1-phenyltridec-1-yn-4-ol
  参考文献：
  名称：

  Indium-Mediated Reaction of 3-Bromo-3,3-difluoropropene and Bromodifluoromethylacetylene Derivatives with Aldehydes

  摘要：

  Aldehydes reacted with 3-bromo-3,3-difluoropropene at the a-position in the presence of indium to afford 1-substituted-2,2-difluorobut-3-en-1-ols. Ketones and other electrophiles are inert under the examined conditions. The reaction of bromodifluoromethyl-acetylene derivatives with an aldehyde in the presence of indium provided difluorohomopropargylic alcohols. These reactions efficiently proceeded in polar solvents (water, DMF) under mild conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00749-3

文献信息

• Indium-Mediated Reaction of 3-Bromo-3,3-difluoropropene and Bromodifluoromethylacetylene Derivatives with Aldehydes
  作者：Masayuki Kirihara、Tomofumi Takuwa、Shinobu Takizawa、Takefumi Momose、Hideo Nemoto

  DOI：10.1016/s0040-4020(00)00749-3

  日期：2000.10

  Aldehydes reacted with 3-bromo-3,3-difluoropropene at the a-position in the presence of indium to afford 1-substituted-2,2-difluorobut-3-en-1-ols. Ketones and other electrophiles are inert under the examined conditions. The reaction of bromodifluoromethyl-acetylene derivatives with an aldehyde in the presence of indium provided difluorohomopropargylic alcohols. These reactions efficiently proceeded in polar solvents (water, DMF) under mild conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.