(2Z)-2-[(5-bromo-2-hydroxyphenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 橙酮类黄酮
• 英文名称: (2Z)-2-[(5-bromo-2-hydroxyphenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one
• 化学式: C₁₅H₉BrO₅
• 分子量: 349.13
• InChiKey: ASNWPFIAIKYLDX-SDQBBNPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Aurones as telomerase inhibitors
  申请人：——

  公开号：US20040132807A1

  公开（公告）日：2004-07-08

  The present invention relates to know and novel substituted aurones active as telomerase inhibitors, to their use as therapeutic agents, in particular as antitumoral agents, to a process for their preparation as to pharmaceutical compositions comprising them.

  本发明涉及一种新颖的取代的黄酮类化合物，作为端粒酶抑制剂的活性，以及它们作为治疗剂，特别是抗肿瘤剂的用途，以及它们的制备过程和包含它们的制药组合物。
• AURONES AS TELOMERASE INHIBITORS
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1381359A1

  公开（公告）日：2004-01-21
• [EN] AURONES AS TELOMERASE INHIBITORS<br/>[FR] AURONES UTILES COMME INHIBITEURS DE LA TELOMERASE
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2002083123A1

  公开（公告）日：2002-10-24

  The present invention relates to know and novel substituted aurones active as telomerase inhibitors, to their use as therapeutic agents, in particular as antitumoral agents, to a process for their preparation as to pharmaceutical compositions comprising them.