2-[(4-羟基-3-甲氧基苯基)亚甲基]-7-甲氧基-1-苯并呋喃-3-酮 | 6307-94-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 橙酮类黄酮
• 中文名称: 2-[(4-羟基-3-甲氧基苯基)亚甲基]-7-甲氧基-1-苯并呋喃-3-酮
• 英文名称: (2E)-2-[(4-hydroxy-3-methoxyphenyl)methylidene]-7-methoxy-1-benzofuran-3-one
• CAS: 6307-94-4
• 化学式: C₁₇H₁₄O₅
• 分子量: 298.29
• InChiKey: YOCXMJWCELPPMX-OQLLNIDSSA-N

物化性质

• 熔点：
  199-200.5 °C
• 沸点：
  509.9±50.0 °C(Predicted)
• 密度：
  1.354±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] MDRI-INVERSE AGENTS<br/>[FR] AGENTS S'OPPOSANT AU GÈNE MDR1
  申请人：US HEALTH

  公开号：WO2010138686A1

  公开（公告）日：2010-12-02

  A method for inhibiting the growth of drug resistant cells in a subject, comprising identifying a subject having drug resistant cells; and administering to the subject a compound or a pharmaceutically acceptable salt or ester thereof, that is a MDR1 -inverse agent. Also disclosed is a method of inhibiting cancer in a subject, comprising administering to the subject an antiproliferative agent, wherein the antiproliferative effect of the agent is potentiated by P-glycoprotein and the agent is a compound, or a pharmaceutically acceptable salt or ester thereof, that is a MDR1 -inverse agent.