methyl (5S,6R,7E,9E,11Z,13E,15S)-5,6-dihydroxy-15-(hydroxymethyl)icosa-7,9,11,13-tetraenoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl (5S,6R,7E,9E,11Z,13E,15S)-5,6-dihydroxy-15-(hydroxymethyl)icosa-7,9,11,13-tetraenoate
• 化学式: C₂₂H₃₆O₅
• 分子量: 380.5
• InChiKey: SRSGCNYYCZUHKU-SWQJIZIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Methods for increasing oral osteogenesis using lipoxin A4 (LXA4) and its analogs
  申请人：Forsyth Dental Infirmary for Children

  公开号：US10434080B2

  公开（公告）日：2019-10-08

  The invention provides methods for increasing oral osteogenesis using LXA4 and its analogs. Methods are also provided for treating or preventing oral disorders that would benefit from increased oral osteogenesis using LXA4 and its analogs.

  本发明提供了使用 LXA4 及其类似物增加口腔成骨的方法。本发明还提供了使用 LXA4 及其类似物治疗或预防口腔疾病的方法，这些口腔疾病可从增加口腔成骨过程中获益。
• LIPOXIN ANALOGS AND METHODS FOR THE TREATMENT OF PERIODONTAL DISEASE
  申请人：Van Dyke Thomas E.

  公开号：US20090311201A1

  公开（公告）日：2009-12-17

  This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond theoral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
• Methods for Increasing Oral Osteogenesis Using Lipoxin A4 (LXA4) and Its Analogs
  申请人：FORSYTH DENTAL INFIRMARY FOR CHILDREN

  公开号：US20160000741A1

  公开（公告）日：2016-01-07

  The invention provides methods for increasing oral osteogenesis using LXA 4 and its analogs. Methods are also provided for treating or preventing oral disorders that would benefit from increased oral osteogenesis using LXA 4 and its analogs.
• Methods for Stabilizing Atherosclerotic Plaques Using Lipoxins, Resolvins, and Analogs Thereof
  申请人：The Forsyth Institute

  公开号：US20180078519A1

  公开（公告）日：2018-03-22

  The invention provides methods for increasing plaque stabilization using LXA4, Resolvin E1, or analog thereof. Methods are also provided for treating or preventing arterial disorders that would benefit from increased plaque stabilization using LXA4, Resolvin E1, or analog thereof.
• COMPOSITIONS AND METHODS OF TREATING CANCER USING LIPID AGONISTS AND RECEPTORS THEREOF
  申请人：Forsyth Dental Infirmary for Children

  公开号：US20200330551A1

  公开（公告）日：2020-10-22

  Provided herein are methods for preventing or treating cancer in a subject comprising overexpressing at least one Receptor for a lipid agonist, such as G-protein receptors for Resolvin. Such methods may be combined with administering Resolvins, or lipoxins and their analogs, of said Receptors to enhance the pro-resolution effects of the Resolvins, or lipoxins and their analogs, in the local, inflammatory environment where cancer cells are already present.