octyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: octyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
• 化学式: C₁₇H₂₇NO₄
• 分子量: 309.4
• InChiKey: APIGBMULEBQONI-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Continuous Administration of Levodopa and/or Dopa Decarboxylase Inhibitors and Compositions for Same
  申请人：NEURODERM, LTD.

  公开号：US20130253056A1

  公开（公告）日：2013-09-26

  Disclosed herein are for example, liquid aqueous compositions that include for example an ester or salt of levodopa, or an ester or salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome, dystonia, and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of levodopa and/or carbidopa or ester and/or salt thereof.