(E)-2-decenamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (E)-2-decenamide
• 英文别名: E-dec-2-enamide；2E-decenamide；trans-dec-2-enamide；trans-Dec-2-enamid；(E)-dec-2-enamide
• 化学式: C₁₀H₁₉NO
• 分子量: 169.267
• InChiKey: HOHPPAHUSJCHHL-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 作用下， 生成 (E)-2-decenamide
  参考文献：
  名称：

  Fonteyn, Bulletin des Societes Chimiques Belges, 1934, vol. 43, p. 189

  摘要：

  DOI：

文献信息

• TRANS-2-DECENOIC ACID DERIVATIVE AND PHARMACEUTICAL AGENT CONTAINING THE SAME
  申请人：Iinuma Munekazu

  公开号：US20130225837A1

  公开（公告）日：2013-08-29

  An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1): (In the formula, Y is —O—, —NR— or —S—, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury.

  本发明的目的是提供一种新的反式-2-癸烯酸衍生物或其药用盐，并提供一种包含该化合物作为活性成分并具有高度安全的神经营养因子样活性或对抗癌药物引起的副作用的缓解作用的药物制剂。本发明的反式-2-癸烯酸衍生物或其药用盐具体由化学式(1)表示：(在该式中，Y为—O—、—NR—或—S—，R为氢原子、烷基、二烷基氨基烷基或类似物，W为二烷基氨基烷基等取代基)，作为一种药用制剂，具有预防或治疗痴呆症、阿尔茨海默病、帕金森病、抑郁症等的药物，以及治疗或修复脊髓损伤的药物，具有非常高的实用性。
• Sequential Synthesis of (<i>E</i>)-α,β-Unsaturated Primary Amides with Complete Stereoselectivity
  作者：José M. Concellón、Humberto Rodríguez-Solla、Carmen Concellón、Carmen Simal、Noemí Alvaredo

  DOI：10.1021/jo100320j

  日期：2010.5.21

  A novel, efficient, and totally stereoselective synthesis of (E)-α,β-unsaturated primary amides is reported. This process is consistent with a SmI2-mediated sequential reaction of an unmasked samarium chloroacetamide enolate with an aldehyde, followed by a β-elimination to produce (E)-α,β-unsaturated primary amides in good yields.

  报道了（E）-α，β-不饱和伯酰胺的新颖，有效且完全立体选择性的合成。该过程与未掩蔽的氯乙酰胺mar烯酸酯与醛的SmI 2介导的顺序反应一致，然后进行β-消除，以高收率生产（E）-α，β-不饱和伯酰胺。
• Temperature-responsive polymer compound and process for producing the same
  申请人：Akiyama Yoshikatsu

  公开号：US20050224415A1

  公开（公告）日：2005-10-13

  A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by varying the side chain is provided. The process for production thereof and the use thereof are also provided.

  提供了一种温度敏感的聚合物和聚合物材料，其在侧链中的一个或多个位置具有酯键和/或酸酰胺键，并且可以通过改变侧链任意控制。同时还提供了其生产过程和使用方法。
• Ethylene alpha-olefin polymer substituted Mannich base lubricant dispersant additives
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0356010A1

  公开（公告）日：1990-02-28

  The present invention is directed to oil-soluble lubricating oil additives comprising Mannich Base condensates of an alkyl substituted hydroxy aromatic compound with formaldehyde and an amine, wherein the alkyl-moiety of the aromatic compounds is derived from at least one ethylene alpha-olefin copolymer of 300 to 10,000 number average molecular weight, wherein at least about 30% of the polymer's chains contain terminal ethenylidene unsaturation. The Mannich Base condensates of this invention are useful as dispersants.

  本发明涉及油溶性润滑油添加剂，包括烷基取代的羟基芳香化合物与甲醛和胺的曼尼希碱缩合物，其中芳香化合物的烷基分子来自至少一种平均分子量为 300 至 10,000 的乙烯-α-烯烃共聚物，其中至少约 30% 的聚合物链含有末端乙烯不饱和。本发明的曼尼希碱缩合物可用作分散剂。
• Ethylene alpha-olefin copolymer substituted amino phenol mannich base lubricant dispersant additives
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0357217A2

  公开（公告）日：1990-03-07

  The present invention is directed to oil-soluble lubricating oil additives comprising Mannich Base condensates of (A) and ethylene-alpha-olefin polymer substituted mono- or dicarboxylic acid material, (B) an optionally alkyl-substituted N-hydroxyaryl compound, (C) an aldehyde, and (D) an amine, wherein the polyer moiety of the mono- or dicarboxylic acid material is derived from at least one terminally unsaturated ethylene alpha-olefin copolymer of 300 to 10,000 number average molecular weight, wherein the terminal unsaturation comprises ethenylidene unsaturation. The Mannich Base condensates of this invention are useful as dispersants.

  本发明涉及油溶性润滑油添加剂，其包含以下物质的曼尼希碱缩合物：(A)和乙烯-α-烯烃聚合物取代的单羧酸或二羧酸材料；(B)任选烷基取代的 N-羟基芳基化合物；(C)醛；和(D)胺、和 (D) 一种胺，其中单羧酸或二羧酸材料的聚合体分子来自至少一种平均分子量为 300 至 10,000 的端基不饱和乙烯-α-烯烃共聚物，其中端基不饱和包括乙烯基不饱和。本发明的曼尼希碱缩合物可用作分散剂。