2-Hydroxy-2-(1,1,2,2-tetrafluoroethyl)-4-nitro-6-(trifluoromethyl)benzimidazoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-Hydroxy-2-(1,1,2,2-tetrafluoroethyl)-4-nitro-6-(trifluoromethyl)benzimidazoline
• 英文别名: 4-nitro-2-(1,1,2,2-tetrafluoroethyl)-6-(trifluoromethyl)-1,3-dihydrobenzimidazol-2-ol
• 化学式: C10H6F7N3O3
• 分子量: 349.16
• InChiKey: LHJGQHSQTKWAHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  90.1
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  2-Hydroxy-2-(1,1,2,2-tetrafluoroethyl)-4-nitro-6-(trifluoromethyl)benzimidazoline sodium salt 、 silver nitrate 以yielding 2-hydroxy-2-(1,1,2,2-tetrafluoroethyl)-4-nitro-6-(trifluoromethyl)benzimidazoline, silver salt的产率得到2-Hydroxy-2-(1,1,2,2-tetrafluoroethyl)-4-nitro-6-(trifluoromethyl)benzimidazoline
  参考文献：
  名称：

  2-Oxybenzimidazoline compounds

  摘要：

  本发明涉及2-羟基和2-烷氧基苯并咪唑化合物，其具有除草、杀虫和驱虫活性。

  公开号：

  US04265901A1

文献信息

• Benzimidazoline salts, their preparation and compositions containing them
  申请人：ELI LILLY AND COMPANY

  公开号：EP0031699A1

  公开（公告）日：1981-07-08

  Benzimidazoline salts of formula (I): wherein: Rn(+) represents a cation having a valency of n, n being an integer from 1 to 3; R1 represents halo or trifluoromethyl; R2 represents hydrogen or C1-4 alkyl; and R3 represents hydrogen, or fluoro or C1-3 fluoroalkyl, have been found to be effective ectoparasiticides.

  式（I）的苯并咪唑啉盐：其中：Rn(+) 代表阳离子，阳离子的化合价为 n，n 为 1 至 3 的整数；R1 代表卤代或三氟甲基；R2 代表氢或 C1-4 烷基；R3 代表氢或氟或 C1-3 氟烷基。
• Amine salts
  申请人：ELI LILLY AND COMPANY

  公开号：EP0113945A1

  公开（公告）日：1984-07-25

  Amine salts of benzimidazole compounds, of the formula wherein R1 is bromo, chloro, -CF3, -CF2Br, or -CF2Cl; R2 is perfluoroalkyl of C1-C3 or -CF2-CF2R3 wherein R3 is hydrogen or C1-C6 alkyl; R4 is a substituted ammonium cation derived from an organic amine; and n is the valence of R4, the said salt having a Kow > 150 in the system octanol/water, are useful as ectoparasiticides and as agents for the control of colonial insects.

  式中苯并咪唑化合物的胺盐 其中 R1 是溴、氯、-CF3、-CF2Br 或 -CF2Cl；R2 是 C1-C3 的全氟烷基或 -CF2-CF2R3，其中 R3 是氢或 C1-C6 烷基；R4 是来自有机胺的取代铵阳离子；n 是 R4 的化合价，上述盐在辛醇/水体系中的 Kow > 150，可用作外寄生虫杀虫剂和防治殖生昆虫的制剂。
• Phenylenediamine or benzimidazole derivatives for treating coccidiosis
  申请人：ELI LILLY AND COMPANY

  公开号：EP0616806A1

  公开（公告）日：1994-09-28

  The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed to anticoccidial methods, animal feed premixes, and animal feeds employing two active agents. In such combined therapy, a first substance is a polyether antibiotic, and the second substance is a designated o-phenylenediamine, benzimidazole, or benzimidazoline.

  本发明涉及采用特定邻苯二胺或苯并咪唑的抗球虫方法、动物饲料预混料和动物饲料。本发明还涉及采用两种活性剂的抗球虫方法、动物饲料预混料和动物饲料。在这种联合疗法中，第一种物质是聚醚抗生素，第二种物质是指定的邻苯二胺、苯并咪唑或苯并咪唑啉。
• Anticoccidial methods and feedstuffs
  申请人：ELI LILLY AND COMPANY

  公开号：EP0821953A2

  公开（公告）日：1998-02-04

  The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed to anticoccidial methods, animal feed premixes, and animal feeds employing two active agents. In such combined therapy, a first substance is a polyether antibiotic, and the second substance is a designated o-phenylenediamine, benzimidazole, or benzimidazoline.

  本发明涉及采用特定邻苯二胺或苯并咪唑的抗球虫方法、动物饲料预混料和动物饲料。本发明还涉及采用两种活性剂的抗球虫方法、动物饲料预混料和动物饲料。在这种联合疗法中，第一种物质是聚醚抗生素，第二种物质是指定的邻苯二胺、苯并咪唑或苯并咪唑啉。
• US4265901A
  申请人：——

  公开号：US4265901A

  公开（公告）日：1981-05-05