(E)-N,N-diethyl-3-[4-[5-(2-phenoxyethylsulfanylmethyl)-1,3,4-oxadiazol-2-yl]phenyl]prop-2-en-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-N,N-diethyl-3-[4-[5-(2-phenoxyethylsulfanylmethyl)-1,3,4-oxadiazol-2-yl]phenyl]prop-2-en-1-amine
• 化学式: C₂₄H₂₉N₃O₂S
• 分子量: 423.6
• InChiKey: YIUZDEZBJSGXDO-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  76.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes
  申请人：Ammenn Jochen

  公开号：US20050272718A1

  公开（公告）日：2005-12-08

  The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

  本发明涉及一种式 I 的黑色素浓缩激素拮抗剂化合物：(I)；或其药学上可接受的盐、溶液剂、对映体或原药，可用于治疗、预防或改善与肥胖及相关疾病有关的症状。
• MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1505968A1

  公开（公告）日：2005-02-16
• US7229987B2
  申请人：——

  公开号：US7229987B2

  公开（公告）日：2007-06-12
• [EN] MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES<br/>[FR] COMPOSES MULTICYCLIQUES QUE L'ON UTILISE COMME ANTAGONISTES DE L'HORMONE DE CONCENTRATION DE MELANINE DANS LE TRAITEMENT DE L'OBESITE ET DU DIABETE
  申请人：LILLY CO ELI

  公开号：WO2003097047A1

  公开（公告）日：2003-11-27

  The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I);or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.