(2R)-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-hydroxy-5-[[(1R)-1-phenylethyl]carbamoylamino]pentanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-hydroxy-5-[[(1R)-1-phenylethyl]carbamoylamino]pentanamide
• 化学式: C₁₈H₂₃ClN₄O₅S₂
• 分子量: 474.989
• InChiKey: NJYAOCXRRHNHBL-TZMCWYRMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  173
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-氯噻唑-2-磺酰氯 、 (R)-(+)-1-苯乙基异氰酸酯 、 N-芴甲氧羰基-(N’-叔丁氧羰基)-D-鸟氨酸 生成 (2R)-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-hydroxy-5-[[(1R)-1-phenylethyl]carbamoylamino]pentanamide
  参考文献：
  名称：

  Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-Proteinase: solid-Phase synthesis of ornithine analogues

  摘要：

  A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00384-5

文献信息

• Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-Proteinase: solid-Phase synthesis of ornithine analogues
  作者：Sharon M. Dankwardt、Robert L. Martin、Christine S. Chan、Harold E. Van Wart、Keith A.M. Walker、Nancy G. Delaet、Leslie A. Robinson

  DOI：10.1016/s0960-894x(01)00384-5

  日期：2001.8

  A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP). (C) 2001 Elsevier Science Ltd. All rights reserved.