Ac-Phe-Orn(1)-Val-D-Cha-Trp-Arg-(1)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ac-Phe-Orn(1)-Val-D-Cha-Trp-Arg-(1)
• 英文别名: (2S)-2-acetamido-N-[(3S,6S,9R,12S,15S)-9-(cyclohexylmethyl)-3-[3-(diaminomethylideneamino)propyl]-6-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazacyclooctadec-15-yl]-3-phenylpropanamide
• 化学式: C₄₇H₆₇N₁₁O₇
• 分子量: 898.1
• InChiKey: INSNQJXZZQIAPD-HPSWDUTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  65
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  284
• 氢给体数：
  10
• 氢受体数：
  8

文献信息

• TREATMENT OF OSTEOARTHRITIS
  申请人：Shiels Ian Alexander

  公开号：US20100267639A1

  公开（公告）日：2010-10-21

  This invention relates to methods of treatment of osteoarthritis, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the invention are disclosed.
• US7579432B2
  申请人：——

  公开号：US7579432B2

  公开（公告）日：2009-08-25
• US7659246B2
  申请人：——

  公开号：US7659246B2

  公开（公告）日：2010-02-09