N-(4-Diethylsulfamoyl-phenyl)-2,2-diphenyl-acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-Diethylsulfamoyl-phenyl)-2,2-diphenyl-acetamide
• 英文别名: N-[4-(diethylsulfamoyl)phenyl]-2,2-diphenylacetamide
• 化学式: C₂₄H₂₆N₂O₃S
• 分子量: 422.548
• InChiKey: VBVBMKJZVBPYHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2-二苯基乙酸 、 4-氨基-N,N-二乙基苯磺酰胺 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 生成 N-(4-Diethylsulfamoyl-phenyl)-2,2-diphenyl-acetamide
  参考文献：
  名称：

  Neuropeptide Y antagonists

  摘要：

  这种化合物是一种神经肽Y拮抗剂，对治疗进食障碍、心血管疾病和其他生理紊乱有效。

  公开号：

  US06407120B1

文献信息

• Amide derivatives useful as Neuropeptide Y (NPY) antagonists
  申请人：Pfizer Products Inc.

  公开号：EP1033366A3

  公开（公告）日：2000-12-27

  A compound of the formula: wherein: K is phenyl, 2-pyridyl. 3-pyridyl or 4-pyridyl, each ring optionally substituted with one to three substituents selected from halogen, C1-C3alkyl, C1-C3perfluoroalkyl, C1-C3alkoxy and C1-C3perfluoroalkoxy; L is H, C3-C8cycloalkyl, phenyl, 2-pyridyl, 3-pyridyl or 4-pyridyl; wherein each phenyl and pyridyl ring may be substituted with one to three substituents selected from C1-C3alkyl, C1-C3alkoxy and halogen;Z IS -COR3, -CONR1R2, -NR1R2 and SO2R4;X and Y are CH or N, with the proviso that one of X and Y must be CH;n is an integer from 0 to 3;m and p are independently selected from the integers 1 to 3;Q is O, NR, CHR;R is hydrogen or C1-C6alkyl;R1 and R2 are independently selected from hydrogen, C1-C6alkyl, (CH2)mphenyl, (CH2)mpyridyl, or R1 and R2 may be taken together with the nitrogen to which they are attached to form a 4 to 8 numbered ring optionally containing O, NH or NR;R3 is C1-C6alkyl; R4 is -NR1R2, -NH(CH2)mphenyl, -N(C4-C8cycloalkyl)2 and -NH(C4-C8cycloalkyl); or a pharmaceutically acceptable salt thereof.The compound is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.

  一个化合物的公式：其中：K是苯基，2-吡啶基，3-吡啶基或4-吡啶基，每个环可选择地用从卤素，C1-C3烷基，C1-C3全氟烷基，C1-C3烷氧基和C1-C3全氟烷氧基中选择的一个到三个取代基取代；L是H，C3-C8环烷基，苯基，2-吡啶基，3-吡啶基或4-吡啶基；其中每个苯基和吡啶基环可用从C1-C3烷基，C1-C3烷氧基和卤素中选择的一个到三个取代基取代；Z是-COR3，-CONR1R2，-NR1R2和SO2R4；X和Y是CH或N，条件是X和Y中的一个必须是CH；n是从0到3的整数；m和p是独立地从整数1到3中选择的；Q是O，NR，CHR；R是氢或C1-C6烷基；R1和R2是独立地从氢，C1-C6烷基，(CH2)m苯基，(CH2)m吡啶基中选择，或R1和R2可以与它们连接的氮一起形成一个含有O，NH或NR的4到8编号环；R3是C1-C6烷基；R4是-NR1R2，-NH(CH2)m苯基，-N(C4-C8环烷基)2和-NH(C4-C8环烷基)；或其药学上可接受的盐。该化合物是一种神经肽Y拮抗剂，对治疗进食障碍，心血管疾病和其他生理障碍有效。
• PYY and agonists thereof for modification of feeding behaviour
  申请人：Imperial Innovations Limited

  公开号：EP2050460A1

  公开（公告）日：2009-04-22

  Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.

  本发明公开了减少受试者卡路里摄入量、食物摄入量和食欲的方法。 这些方法包括向受试者外周施用治疗有效量的PYY或其激动剂，从而减少受试者的卡路里摄入量。
• Assessment of neurons in the arcuate nucleus to screen for agents that modify feeding behavior
  申请人：Cowley Michael

  公开号：US20050015820A1

  公开（公告）日：2005-01-20

  Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used to identify agents of use in treating anorexia or cachexia and can be used to increase appetite and to increase the weight and lean body mass of a subject.

  本文公开了用于鉴定影响热量摄入、食物摄入、食欲和能量消耗的制剂的筛选方法。这些方法可用于鉴定治疗肥胖症或可用于减轻受试者体重的药物。这些方法还可用于确定治疗厌食症或恶病质的药物，并可用于增加食欲和增加受试者的体重和瘦体重。
• EP1499277A4
  申请人：——

  公开号：EP1499277A4

  公开（公告）日：2005-08-31
• MODIFICATION OF FEEDING BEHAVIOR
  申请人：Imperial College Innovations Limited

  公开号：EP1499277A2

  公开（公告）日：2005-01-26