1-(2,2-diphenyl-ethyl)-4-methyl-piperazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,2-diphenyl-ethyl)-4-methyl-piperazine
• 英文别名: 1-(2,2-Diphenyl-aethyl)-4-methyl-piperazin；1-(2,2-Diphenylethyl)-4-methylpiperazine
• 化学式: C₁₉H₂₄N₂
• 分子量: 280.413
• InChiKey: SVLDAGDSXNFTJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2-二苯基乙酸 在 吡啶 、 lithium aluminium tetrahydride 、 氯化亚砜 、 乙醚 、 sodium carbonate 、 xylene 作用下， 生成 1-(2,2-diphenyl-ethyl)-4-methyl-piperazine
  参考文献：
  名称：

  Histamine Antagonists. II.¹ Unsymmetrical 1,4-Disubstituted Piperazines

  摘要：

  DOI：

  10.1021/ja01176a038

文献信息

• N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS
  申请人：Elmore Steven W.

  公开号：US20100035879A1

  公开（公告）日：2010-02-11

  Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有公式的化合物是凋亡促进剂。还公开了制备这些化合物的方法、含有这些化合物的组合物以及使用这些化合物的治疗方法。
• N-SULFONYLUREA APOPTOSIS PROMOTERS
  申请人：Elmore Steven W.

  公开号：US20080146572A1

  公开（公告）日：2008-06-19

  Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有以下化学式的化合物是凋亡促进剂。还公开了制备这些化合物的方法，含有这些化合物的组合物以及使用这些化合物进行治疗的方法。
• Unsymmetrically Substituted Piperazines. XII.¹ Benzhydrylpiperazines and Related Compounds with Spasmolytic and Anti-Fibrillatory Action²
  作者：WALTER S. IDE、EMIL LORZ、ARTHUR P. PHILLIPS、PETER B. RUSSELL、RICHARD BALTZLY、ROBERT BLUMFELD

  DOI：10.1021/jo01086a005

  日期：1959.4
• Selected Tetracyclic Tetrahydrofuran Derivatives Containing a Cyclic Amine Side Chain
  申请人：Fernandez-Gadea Francisco Javier

  公开号：US20080214572A1

  公开（公告）日：2008-09-04

  This invention concerns novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain with binding affinities towards serotonin receptors, in particular 5-HT 2A and 5-HT 2C receptors, and towards dopamine receptors, in particular dopamine D 2 receptors, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof, and a quaternary ammonium salt thereof, wherein all substituents are defined as in claim 1.
• US7358251B2
  申请人：——

  公开号：US7358251B2

  公开（公告）日：2008-04-15