7-benzyl-3-[2-(3,4-dimethoxyphenyl)ethyl]-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-imine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 7-benzyl-3-[2-(3,4-dimethoxyphenyl)ethyl]-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-imine
• 英文别名: 7-benzyl-3-[2-(3,4-dimethoxyphenyl)ethyl]-5,6-diphenylpyrrolo[2,3-d]pyrimidin-4-imine
• 化学式: C₃₅H₃₂N₄O₂
• 分子量: 540.7
• InChiKey: UUSIUROFVFSCGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS<br/>[FR] COMPOSÉS ET MÉTHODE DE PRÉVENTION ET DE TRAITEMENT DES MÉTASTASES TUMORALES ET DE LA TUMORIGENÈSE
  申请人：US HEALTH

  公开号：WO2013090912A1

  公开（公告）日：2013-06-20

  The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.

  本公开提供了一种化合物，用于减少细胞中周核质区的普遍性，例如式（I）中定义的R1、R2、R3和R4，这些化合物对于治疗与周核质区增加普遍性相关的疾病或障碍，例如癌症，是有用的。还公开了一种含有药学上可接受载体和至少一种体现本发明原则的化合物的组合物，以及一种在哺乳动物中治疗或预防癌症的方法。
• Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：US10301314B2

  公开（公告）日：2019-05-28

  The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.

  本发明公开了用于降低细胞核周室流行率的化合物，例如，式（I）化合物，其中 R1、R2、R3 和 R4 如本文所定义，可用于治疗与细胞核周室流行率增加有关的疾病或紊乱，如癌症。还公开了一种含有药学上可接受的载体和至少一种体现本发明原理的化合物的组合物，以及一种治疗或预防哺乳动物癌症的方法。
• Autophagy inducers for treatment of CNS conditions
  申请人：Northwestern University

  公开号：US11241436B2

  公开（公告）日：2022-02-08

  The invention provides a compound of formula (I): wherein R1, R2, R3, and R4 are as defined herein, ginsenoside Rg2 of structure (II): or a combination thereof, for use in treating or preventing a condition responsive to the induction of autophagy in a brain of a mammal in need thereof.

  本发明提供了一种式（I）：其中 R1、R2、R3 和 R4 如本文所定义的化合物，结构（II）：或其组合的人参皂苷 Rg2，用于治疗或预防需要其的哺乳动物大脑中对自噬诱导有反应的病症。
• COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS
  申请人：The U.S.A. as represented by the Secretary, Department of Health and Human Services

  公开号：EP2791142B1

  公开（公告）日：2019-07-03
• US9663521B2
  申请人：——

  公开号：US9663521B2

  公开（公告）日：2017-05-30