rac-((1S*,2R*)-6,7-dimethoxy-2,3-diphenyl-1,2-dihydronaphthalen-1-yl)(phenyl)methanone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: rac-((1S*,2R*)-6,7-dimethoxy-2,3-diphenyl-1,2-dihydronaphthalen-1-yl)(phenyl)methanone
• 英文别名: [(1S,2R)-6,7-dimethoxy-2,3-diphenyl-1,2-dihydronaphthalen-1-yl]-phenylmethanone
• 化学式: C₃₁H₂₆O₃
• 分子量: 446.546
• InChiKey: NKEZXCGAXACJCQ-LOYHVIPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  反式-1,2-二苯乙烯 、 以 乙腈 为溶剂， 反应 1.0h， 以80%的产率得到rac-((1S*,2R*)-6,7-dimethoxy-2,3-diphenyl-1,2-dihydronaphthalen-1-yl)(phenyl)methanone
  参考文献：
  名称：

  Construction of Multiring Frameworks by Metal-Free Cascade Reactions of Stable Isochromenylium Tetrafluoroborate

  摘要：

  Efficient methodologies for constructing several multiring frameworks have been developed utilizing the cascade reactions of air-stable isochromenylium tetrafluoroborates with olefins. Successive additions of two equivalents of styrene-type olefins to isochromenylium tetrafluoroborate (ICTB) I have been observed and their mechanisms were proposed and discussed. Intramolecular capture of the early stage cat ionic intermediates by predevised heteroatoms or Friedel-Crafts donors provided two different types of bridged-ring systems.

  DOI：

  10.1021/jo902051g