9-(1-(3-fluorophenyl)-2-nitroethyl)anthracen-10(9H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 9-(1-(3-fluorophenyl)-2-nitroethyl)anthracen-10(9H)-one
• 英文别名: 10-[1-(3-fluorophenyl)-2-nitroethyl]-10H-anthracen-9-one
• 化学式: C₂₂H₁₆FNO₃
• 分子量: 361.372
• InChiKey: SLTUJPXEXRWTMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  蒽酮 、 1-fluoro-3-(2-nitrovinyl)benzene 在 1-[3,5-双（三氟甲基）苯基]-3-[（1S，2S）-（+）-2-（二甲基氨基）环己基]硫脲 作用下， 以 甲苯 为溶剂， 反应 36.0h， 以80%的产率得到9-(1-(3-fluorophenyl)-2-nitroethyl)anthracen-10(9H)-one
  参考文献：
  名称：

  Enantioselective Michael addition of anthrone to nitroalkenes catalyzed by bifunctional thiourea-tertiary amines

  摘要：

  A highly bifunctional thiourea-tertiary amine-catalyzed enantioselective Michael addition reaction of anthrone to a wide variety of nitroalkenes has been developed, and the corresponding adducts were obtained smoothly in high yields (up to 97%) and good enantioselectivities (up to 94% ee). Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.09.023

文献信息

• Enantioselective Michael addition of anthrone to nitroalkenes catalyzed by bifunctional thiourea-tertiary amines
  作者：Yu-Hua Liao、Hui Zhang、Zhi-Jun Wu、Lin-Feng Cun、Xiao-Mei Zhang、Wei-Cheng Yuan

  DOI：10.1016/j.tetasy.2009.09.023

  日期：2009.10

  A highly bifunctional thiourea-tertiary amine-catalyzed enantioselective Michael addition reaction of anthrone to a wide variety of nitroalkenes has been developed, and the corresponding adducts were obtained smoothly in high yields (up to 97%) and good enantioselectivities (up to 94% ee). Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.